1384542-75-9

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 693285-71-1 4-bromo-3-isopropyl-1H-indazole 
• 1260539-15-8 4-bromo-2-(tert-butylamino)benzonitrile 
• 1384542-72-6 3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazole 

Downstream Products

• 1384542-20-4 2-(tert-butylamino)-4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)benzamide 

Relevant academic research and scientific papers

NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF

The present invention relates to provision of a novel indazole compound which is capable of inhibiting HSP90 and shows a cytostatic effect on cancer cells. The present invention also relates to provision of a drug useful for preventing and/or treating, on the basis of an HSP90 inhibitory effect, a disease in which HSP90 participates, in particular, cancer. A compound represented by the general formula (I) or a salt thereof: wherein X represents CH or N;any one or two of Y1, Y2, Y3, and Y4 represent C—R3 or N, and the others represent CH;A and B are the same or different and represent an optionally substituted monocyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O;R1 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.;R2 represents a hydrogen atom, a halogen atom etc.;R3 represents a hydrogen atom, a halogen atom etc.;R4 and R5 are the same or different and represent a hydroxyl group etc.;R6 and R7 are the same or different and represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms etc.; andR8 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.