138457-97-3

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-amino-2-ethyl-, methyl ester, (1S-trans)- (9CI)
• Synonyms: Cyclopropanecarboxylic acid, 1-amino-2-ethyl-, methyl ester, (1S-trans)- (9CI);methyl (1S,2S)-1-amino-2-ethyl-cyclopropanecarboxylate
• CAS NO: 138457-97-3
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.18362
• Product Categories: AMINOACID;CARBOXYLICESTER
• Mol File: 138457-97-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-amino-2-ethyl-, methyl ester, (1S-trans)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-amino-2-ethyl-, methyl ester, (1S-trans)- (9CI)(138457-97-3)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-amino-2-ethyl-, methyl ester, (1S-trans)- (9CI)(138457-97-3)

Safety Data

• Hazardous Substances Data: 138457-97-3(Hazardous Substances Data)

Upstream product

• 138387-14-1 (1SR,3SR,6S)-1-Ethyl-3,6-dihydro-6-isopropyl-5,8-dimethoxy-4,7-diazaspiro<2.5>octane 
• 97935-34-7 Potassium; (1R,2S)-2-ethyl-1-methoxycarbonyl-cyclopropanecarboxylate 
• 97935-31-4 2-ethylcyclopropane-1,1-dicarboxylic acid di-tert-butyl ester 
• 18795-92-1 1,1-dimethyl 2-ethylcyclopropane-1,1-dicarboxylate 
• 87429-74-1 3-Azido-4-ethyl-4,5-dihydro-3H-pyrazole-3-carboxylic acid methyl ester 
• 81852-62-2 Methyl (Z)-2-azido-pentenoate 

Downstream Products

• 63393-56-6 (1S,2S)-(+)-1-Amino-2-ethyl-1-cyclopropanecarboxylic Acid 
• 63364-56-7 (+/-)-(E)-1-amino-2-ethylcyclopropanecarboxylic acid 
• 63364-55-6 Methyl trans-2-ethyl-1-(N-methoxycarbonylamino)cyclopropanecarboxylate 

Relevant articles and documents

Asymmetric Synthesis via Heterocyclic Intermediates, XLVII. Asymmetric Synthesis of (+)-(1R,2S)-allo-Coronamic Acid

allo-Coronamic acid (1) was synthesized in five steps enantiomerically and diastereomerically virtually pure by starting from the bislactim ethers of cyclo(-L-Val-Gly-) (3a) or cyclo(-L-tert-Leu-Gly-) (3b) in an overall yield of 31percent.The key step of this synthesis is the intramolecular alkylation of the lithium azaenolate derived from the allylic chloride 4. Key Words: Amino acids / Cyclopropanes / Cyclopropanation, diastereoselective / Bislactim ether method

SYNTHESIS OF 1-AZIDOCYCLOPROPANECARBOXYLATES FROM 2-AZIDO-2-ALKENOATES

Addition of diazomethane to 2-azido-2-alkenoates followed by pyrolysis of the resulting pyrazoline derivatives affords the title compounds.