63393-56-6Relevant articles and documents
Hepatitis C inhibitor peptides
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, (2008/06/13)
Disclosed herein are hepatitis C viral protease inhibitors of formula (I): wherein a is0or1; b is0or1; Y is H or C1-6alkyl; B is H, an acyl derivative or a sulfonyl derivative; R6, when present, is C1-6alkyl substituted wi
A convenient approach to substituted 1-(1-alkenyl)cyclopropanols: A new preparation of 2,3-methanoamino acids
Kozyrkov,Pukin,Kulinkovich,Ollivier,Salaun
, p. 6399 - 6402 (2007/10/03)
The diastereoselective titanium(IV)-mediated cyclopropanation of ethyl 3,3-diethoxypropionate by Grignard reagents, followed by modified Knoevenagel condensation with malonic acid under microwave irradiation, allow the preparation of (E)-1-(1-alkenyl)cyclopropanol derivatives, suitable precursors of πn-1,1-dimethyleneallylmetal species. The azidation of such complexes, followed by a reduction-oxidation sequence led to pure (E)-2,3-methanoamino acids. (C) 2000 Elsevier Science Ltd.
Stereoselective synthesis of highly functionalized cyclopropanes. Application to the asymmetric synthesis of (1S,2S)-2,3-methanoamino acids
Dorizon, Philippe,Su, Guifa,Ludvig, Gitte,Nikitina, Lilyia,Paugam, Renee,Ollivier, Jean,Salauen, Jacques
, p. 4712 - 4724 (2007/10/03)
One-pot palladium(0)-catalyzed alkylation and S(N') cyclization of 1,4- dichlorobut-2-ene 1 by the anion of α-substituted carbonitriles 2a-d can provide highly functionalized cyclopropanes (E)-4a-d, diastereoselectivity, (de 88-100%). Several attempts to achieve the asymmetric synthesis of the 1- amino-2-ethenylcyclopropanecarbonitrile (E)-9, by means of this new procedure, i.e., using chiral palladium ligands, chiral aminoacetonitriles (- )- and (+)-12 (from 1-hydroxypinanone) or chiral allyl chlorides (4S)-20b-d and (4R)-20e (from (2S) ethyl lactate) have pointed up the reversibility of the palladium-catalyzed cyclization step, responsible for the low enantioselectivity observed (ee ≤ 32%) and for the formation of byproducts, i.e., azepine derivatives 8a,b arising from subsequent aza Cope ring expansion. Molecular mechanics calculations using a modified MM2 type force field adapted to the π-allyl palladium complexes have explained these results. However, When performed under the Mitsunobu reaction conditions (DEAD, PMe3), therefore, in the absence of palladium catalyst, the S(N'), cyclization occurred also diastereoselectively (de > 88%) and provided the enantiomerically enriched 1-amino-2-propenylcyclopropanecarbonitrile (E)-22 (ee > 83%) suitable precursor of (1S,2S)-2,3-methanoamino acids.