13846-61-2

Upstream product

• 186581-53-3 diazomethane 
• 113-98-4 Penicillin G potassium 
• 61-33-6 penicillin G 

Downstream Products

• 18521-33-0 [(5R)-3,3-dimethyl-7-oxo-6t-(2-phenyl-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-2c-yl]-acetic acid 
• 63822-47-9 N-((1S)-8,8-dimethyl-3,9-dioxo-(1rC⁹,5tH,6cC⁹)-7-thia-2-aza-tricyclo[4.2.1.0^2,5]non-4t-yl)-2-phenyl-acetamide 
• 118673-37-3 (7R,8S)-2-isopropylidene-8-phenylacetamido-5-oxa-6-thia-1-azabicyclo<5.2.0>nonane-3,9-dione 6-oxide 
• 63822-58-2 N-((1S)-9ξ-hydroxy-8,8-dimethyl-3-oxo-(1rC⁹,5tH,6cC⁹)-7-thia-2-aza-tricyclo[4.2.1.0^2,5]non-4t-yl)-2-phenyl-acetamide 
• 63822-57-1 (S)-((1R)-3,3-dimethyl-7-oxo-2-thia-5-aza-bicyclo[2.2.1]hept-6exo-yl)-(2-phenyl-acetylamino)-acetic acid 
• 63822-51-5 (S)-((1R)-3,3-dimethyl-7-oxo-2-thia-5-aza-bicyclo[2.2.1]hept-6exo-yl)-(2-phenyl-acetylamino)-acetic acid methyl ester 
• 10482-97-0 2-[(5R)-3,3-dimethyl-7-oxo-6t-(2-phenyl-acetylamino)-(5rH)-4-thia-1-aza-bicyclo[3.2.0]hept-2c-yl]-N-phenyl-acetamide 
• 118673-36-2 (3S,5R,6R)-3-diazoacetyl-2,2-dimethyl-6-phenylacetamidopenam 1,1-dioxide 

Relevant academic research and scientific papers

Studies Related to Penicillins. Part 24. A Novel Thiazolidine Ring Enlargement of Penam Dioxides

In the presence of hydrochloric acid, (3S,5R,6R)-3-diazoacetyl-2,2-dimethyl-6-phenoxyacetamidopenam 1,1-dioxide (4c) was converted into the corresponding 3-chloroacetyl derivative (4b), which reacted with 1,5-diazabicyclonon-5-ene (DBN) to give (7R