61-33-6 Usage
Brand Name(s) in US
Penicillin G potassium or sodium: Many brands
Penicillin G benzathine: Benza-Pen, and other names
Penicillin G, Procaine: Generic
Penicillin V: Pen-Vee
Description
Penicillin was the first natural antibiotic used to treat bacterial infections and continues to be one of the most important antibiotics.The name comes from the fungus genus Penicillium from which it was isolated. Penicillus is Latin for brush and refers to the brushlike appearance of filamentous Penicillium species.Species of this genus are quite common and appear as the bluish-green mold that appears on aged bread, fruit, and cheese. The term penicillin is a generic term that refers to a number of antibiotic compounds with the same basic structure. Therefore it is more appropriate to speak of penicillins than of penicillin. The general penicillin structure consists of a β-lactam ring and thiazolidine ring fused together with a peptide bonded to a variable R group. Penicillin belongs to a group of compounds called β-lactam antibiotics. This in turn inhibits the formation of peptidoglycan cross-links in bacteria cell walls.
History
The discovery of penicillin is generally credited to Alexander Fleming (1881 1955) in 1928, but the development of penicillin as an antibiotic took place sporadically over the last decades of the 19th century and first half of the 20th century. Mass production of penicillin by U.S.firms started in 1943,and it was used immediately to treat wounded soldiers. Penicillin reduced suff ering, prevented amputations,cured pneumonia,and saved thousands of lives during the war and was hailed as a miracle drug. The United States increased production throughout the war years and after the war widespread civilian use commenced. Fleming, Florey,and Chain shared the Nobel Prize in physiology or medicine in 1945 for their work on penicillin.
Uses
Different sources of media describe the Uses of 61-33-6 differently. You can refer to the following data:
1. Benzylpenicillin is the drug of choice for infections caused by sensitive organisms. This
includes streptococci infections (except enterococci), gonococci, and meningococci that
do not produce beta-lactam anaerobes. Benzylpenicillin is used for croupous and focal
pneumonia, skin infections, soft tissue and mucous membranes, periotonitis, cystisis,
syphilis, diphtheria, and other infectious diseases. Synonyms of this drug are megacillin,
2. Penicillin is an antimicrobial agent.
3. Antibacterial.
Indications
Benzylpenicillin or penicillin G has a narrow antimicrobial spectrum. It is active with
respect to Gram-positive bacteria (staphylococcus, streptococcus, and pneumococci),
causative agent of diphtheria, and anthrax bacillus. Gram-negative bacteria are resistant to
it. Benzylpenicillin is broken down by stomach acid and destroyed by staphylococcus
penicillinase.
Antimicrobial activity
It has intrinsic activity against almost all Grampositive
pathogens, but is no longer effective against most
staphylococci. Most species of streptococci are susceptible,
including group B streptococci, an important cause of neonatal
infections. Enterococci are more resistant than streptococci.
Other susceptible Gram-positive organisms include
non-β-lactamase-producing Bacillus anthracis and Listeria monocytogenes.
The spirochetes Borrelia burgdorferi and
Treponema pallidum are also susceptible.
The aerobic Gram-negative cocci Neisseria gonorrhoeae
and N. meningitidis were initially highly susceptible to benzylpenicillin,
but β-lactamase-producing strains of gonococci
are now common. H. influenzae and Moraxella catarrhalis
are usually resistant due to β-lactamase production. The
Enterobacteriaceae and most other aerobic Gram-negative
bacilli are resistant, as a result of β-lactamase production
or the impermeability of the bacterial cell wall. Other resistant
organisms include mycobacteria, mycoplasmas, Nocardia
spp., rickettsiae and chlamydiae.
Anaerobic Gram-positive cocci are susceptible in
the absence of β-lactamase production. Most clostridia
strains are susceptible, but resistance can be observed.
Anaerobic Gram-negative bacilli vary in their sensitivity:
the Bacteroides fragilis group is resistant as the result of
β-lactamase action, but many Prevotella and Fusobacterium
spp. are susceptible.
Benzylpenicillin exhibits concentration-dependent bactericidal
activity against growing organisms. Killing of highly susceptible
Gram-positive cocci seldom proceeds to eradication,
with measurable numbers of survivors (‘persisters’), which
are fully susceptible on retesting. Some strains of streptococci
(including group B) and pneumococci show very large numbers
of persisters, resulting in a large difference between the
minimum inhibitory concentration (MIC) and the minimum
bactericidal concentration (MBC), a phenomenon known as
‘tolerance’.
Combination with aminoglycosides results in pronounced
bactericidal synergy.
Acquired resistance
Staph. aureus was originally highly susceptible to benzylpenicillin,
but at least 85–90% of clinical isolates are now
β-lactamase-producing strains. Most clinical isolates of coagulase-
negative staphylococci are also resistant. β-Lactamaseproducing
strains of E. faecalis produce an enzyme identical to
staphylococcal penicillinases, but these strains are increasingly
uncommon. The emergence of penicillin-resistant staphylococci,
enterococci and pneumococci, due to the acquisition
of mosaic PBPs with decreased binding affinity for penicillin,
has been described worldwide. Most strains of penicillin-
resistant Gram-positive clinical isolates also demonstrate
reduced susceptibility to other β-lactam agents but, in rare
cases, cross-resistance is not seen for all cephalosporins.
Strains of N. gonorrhoeae for which the MIC of benzylpenicillin
increased from 0.06 mg/L to >2 mg/L appeared in the
1970s, as the result of the production of modified PBPs with
reduced affinity for β-lactam antibiotics; fully resistant strains
producing TEM-1 β-lactamase also emerged. Currently penicillin
resistance occurs in more than 60% of isolates in some
parts of the world.
Contact allergens
Benzyl penicillin is actually used only intravenously. It
was formerly a frequent cause of contact allergy in
health care workers. Facial contact dermatitis was
recently reported in a nurse.
Pharmacokinetics
Oral absorption: 2–25%
Cmax 0.6 g intramuscular: 12 mg/L
3 g intravenous (3–5 min): 400 mg/L
Plasma half-life: 0.5 h
Volume of distribution: 0.2–0.7 L/kg
Plasma protein binding: 60%
Absorption
Benzylpenicillin is unstable in acid and destroyed in the stomach.
As a result, plasma concentrations obtained after oral
administration are variable, and are depressed by administration
with food. It is absorbed from serous cavities, joints and
the subarachnoid space. It is not absorbed following applications
to the skin, which should be avoided because of the
likelihood
of sensitization.
Distribution
The drug is widely distributed in most tissues and body fluids.
Highest levels are found in the kidney, with lower levels in the
liver, skin and intestines. Low concentrations appear in saliva
and in maternal milk. It does not enter uninflamed bone or
the CSF. Its entry is limited by its low pKa (2.6), which results
in its almost complete ionization and very low lipid–water partition
coefficient at pH 7.4. When the meninges are inflamed,
the concentrations obtained in CSF are around 5% of the
plasma level. In uremia, accumulated organic acids may enter the CSF and compete for transport of penicillin, causing the
concentration to reach convulsive levels.
It diffuses into wound exudates and experimental transudates
when the serum level is high, and enters glandular
secretions and the fetal circulation, whence it is excreted in
increased concentrations into the amniotic fluid. Metabolism and excretion
About 40% is metabolized in the liver, mainly to penicilloic
acid. After oral dosing, unabsorbed drug is largely degraded
by colonic bacteria and little activity remains in the feces.
Concentrations 2–4 times those of the plasma are found in
bile, but 60–90% is excreted in the urine, largely in the first
hour. Probenecid causes a doubling of the peak concentration
and prolongation of the plasma half-life. Other drugs, including
aspirin, sulfonamides and some non-steroidal anti-inflammatory
drugs and diuretics, may prolong the half-life.
Clinical Use
Different sources of media describe the Clinical Use of 61-33-6 differently. You can refer to the following data:
1. Serious infections caused by streptococci (including Str. pneumoniae)
other than meningitis caused by penicillin-resistant pneumococci
Serious infections caused by susceptible strains of staphylococci
Meningococcal septicemia and meningitis
Gonococcal infections caused by susceptible strains
Syphilis (including neurosyphilis) and other spirochetal infections
Anthrax
Actinomycosis
Clostridial infections
Diphtheria (adjunctive therapy to antitoxin and for prevention of carrier state)
Infections with other susceptible organisms, including Listeria
monocytogenes, Pasteurella multocida, Erysipelothrix insidiosa and
Fusobacterium
2. For years, the most popular penicillin has been penicillin G,or benzylpenicillin. In fact, with the exception of patients allergicto it, penicillin G remains the agent of choice for thetreatment of more different kinds of bacterial infection thanany other antibiotic. It was first made available as the watersolublesalts of potassium, sodium, and calcium. These saltsof penicillin are inactivated by the gastric juice and are noteffective when administered orally unless antacids, such ascalcium carbonate, aluminum hydroxide, and magnesiumtrisilicate; or a strong buffer, such as sodium citrate, isadded. Also, because penicillin is absorbed poorly from the intestinal tract, oral doses must be very large, about fivetimes the amount necessary with parenteral administration.Only after the production of penicillin had increased enoughto make low-priced penicillin available did the oral dosageforms become popular. The water-soluble potassium andsodium salts are used orally and parenterally to achieve highplasma concentrations of penicillin G rapidly. The morewater-soluble potassium salt usually is preferred when largedoses are required. Situations in which hyperkalemia is adanger, however, as in renal failure, require use of thesodium salt; the potassium salt is preferred for patients onsalt-free diets or with congestive heart conditions.
Side effects
Benzylpenicillin has low toxicity, except for the nervous system
(into which it does not normally penetrate), where it is
one of the most active convulsants among the β-lactam agents.
Excessively high intravenous doses may induce convulsions
and intrathecal doses should never exceed 12 mg (20 000
units) in adults or 3 mg (5000 units) in a child as a single daily
dose. Inadvertent intravascular administration, especially
direct injection into arteries, can cause serious neurotoxic
damage, including hyperreflexia, myoclonic twitches, seizures
and coma.
Massive intravenous doses of the sodium or potassium
salts can lead to severe or fatal electrolyte disturbances. In
patients treated with large doses of the potassium salt (60 g
or more per day), hyponatremia, hyperkalemia and metabolic
acidosis can develop.
Thrombocytopenia and platelet dysfunction resulting in
coagulopathy and involving several different mechanisms have
been described. Neutropenia associated with fever and allergic
rash appears to be related to total dose, usually in excess of
90 g. Although it can be very severe, in most patients recovery
occurs within a few days of withdrawal of treatment.
Large doses (24 g [40 megaunits] per day intravenously),
or smaller doses given to patients with impaired renal function,
may interfere with platelet function.
The most dramatic untoward response is anaphylactic
shock due to allergy . In addition to the generalized
allergic reactions, particular organs may be damaged by a
variety of immunological mechanisms. Hemolytic anemia
occurs only in patients who have been treated previously
with penicillin, and again receive a prolonged course of large
doses (commonly 12 g per day). Reversible hemolysis is due
to the action of anti-penicillin immunoglobulin G (IgG) on
cells that have absorbed the antibiotic. Nephritis, resulting
in dysuria, pyuria, proteinuria, azotemia and histological evidence of nephritis of allergic origin, is only rarely seen, usually
in patients receiving large doses (12–36 g [20–60 megaunits]
per day).
Safety Profile
Poison by ingestion, intravenous,intracerebral, intraspinal, subcutaneous, and possibly otherroutes. Human (child) systemic effects by parenteral route:changes in cochlear (inner ear) structure or function,convulsions, and dyspnea. Questionable carcin
Drug interactions
Potentially hazardous interactions with other drugs
Reduced excretion of methotrexate.
Metabolism
Benzylpenicillin is metabolised to a limited extent and the
penicilloic acid derivative has been recovered in the urine.
Benzylpenicillin is rapidly excreted in the urine; about
20% of an oral dose appears unchanged in the urine; about
60-90% of an IM dose of benzylpenicillin undergoes
renal elimination, 10% by glomerular filtration and 90% by
tubular secretion, mainly within the first hour.
Significant concentrations occur in bile, but in patients
with normal renal function only small amounts are
excreted via the bile.
Renal tubular secretion is inhibited by probenecid, which
can be given to increase plasma-penicillin concentrations
and prolong half-life.
Check Digit Verification of cas no
The CAS Registry Mumber 61-33-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 61-33:
(4*6)+(3*1)+(2*3)+(1*3)=36
36 % 10 = 6
So 61-33-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12?,14-/m1/s1
61-33-6Relevant articles and documents
Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group
Goto, Yuya,Ueda, Masafumi,Sugikawa, Kouta,Yasuhara, Kazuma,Ikeda, Atsushi
, p. 166 - 171 (2019)
The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365?nm.
-
Sheehan,J.C.,Daves,G.D.
, p. 2006 - 2008 (1964)
-
α-Carboxy-6-nitroveratryl: A photolabile protecting group for carboxylic acids
Russell, Alexander G.,Ragoussi, Maria-Eleni,Ramalho, Rui,Wharton, Christopher W.,Carteau, David,Bassani, Dario M.,Snaith, John S.
supporting information; scheme or table, p. 4648 - 4651 (2010/09/14)
(Figure presented) The synthesis of a new photolabile protecting group for carboxylic acids, α-carboxy-6-nitroveratryl (αCNV), is described. Bromide 3, prepared in four steps from 3,4-dimethoxyphenylacetic acid, was used to alkylate carboxylic acids under mild conditions in good yield. Palladium-catalyzed deallylation afforded the acids 4a-h, which underwent rapid and quantitative photolysis at wavelengths longer than 300 nm to liberate the carboxylic acid in good to quantitative yield. The rate of photolysis and quantum yield were determined to be 325 s-1 and 0.17.
Prop-2-ynyl as a protective group for carboxylic acids: A mild method for the highly selective deprotection of prop-2-ynyl esters using tetrathiomolybdate
Ilankumaran, Palanichamy,Manoj,Chandrasekaran, Srinivasan
, p. 1957 - 1958 (2007/10/03)
It is shown that prop-2-ynyl esters are useful protecting groups for carboxylic acids and that they are selectively deprotected in the presence of other esters on treatment with tetrathiomolybdate under mild conditions.
