138479-08-0Relevant academic research and scientific papers
A secondary amine amide organocatalyst for the asymmetric nitroaldol reaction of α-ketophosphonates
Chen, Xiaohong,Wang, Jun,Zhu, Yin,Shang, Deju,Gao, Bo,Liu, Xiaohua,Feng, Xiaoming,Su, Zhishan,Hu, Changwei
, p. 10896 - 10899 (2008)
A study was conducted for the asymmetric nitroaldol reaction of α-ketophosphonates by using a secondary amine amide organocatalyst. The study used a series of chiral secondary amine amides and synthesized it with α-ketophosphonates with nitromethane used as the solvent at 0°C. The nitroaldol reaction can be used for preparing nitrogen-containing compounds in the organic synthesis. It was observed during the study the α- ketophosphonates can be converted into optically active β-amino-α- hydroxy phosphonates, that further can be used as biological activity intermediates for inhibition of renin of HIV protease. The study also found that secondary amines like diethylamine or piperidine can promote the nitroaldol reaction of α-ketophosphonate at 0°C.
Studies on organophosphorus compounds, 53: A new procedure for the synthesis of 1-alkyl or 1-aryl-1-hydroxy-2-nitroethylphosphonates under PTC conditions
Yuan,Cui,Wang,Feng,Chen,Li,Ding,Maier
, p. 258 - 260 (2007/10/02)
A series of dialkyl 1-alkyl- or 1-aryl-1-hydroxy-2-nitroethyl-phosphonates and 1-hydroxy-1-(nitromethyl)alkylphosphonates was prepared by nucleophilic addition of nitromethane to dialkyl acylphosphonates in the presence of potassium carbonate and tetrabutylammonium bromide.
