138480-32-7Relevant academic research and scientific papers
Synthesis of 2-azabicyclo[4.1.0]heptanes through stereoselective cyclopropanation reactions
Suarez Del Villar, Irene,Gradillas, Ana,Perez-Castells, Javier
experimental part, p. 5850 - 5862 (2011/03/17)
Unsaturated δ-lactams are cyclopropanated with the aid of diazo compound decomposition catalysed by metal complexes. A study of the reaction conditions, stereochemical outcome and group protection is reported. The resulting bicyclic products are related to bioactive compounds. Transformation into thiolactams facilitates the separation of the different isomers obtained and the removal of the protecting group. The cyclopropanation reaction works with diverse diazo compounds. Unsaturated δ-lactams are cyclopropanated with the aid of diazo compound decomposition catalysed by metal complexes. A study of the reaction conditions, stereochemical outcome and group protection isreported. Transformation into thiolactams assists in separation of the different isomers obtained and removal of the protecting group.
Cyclopropanation reactions for the synthesis of 2-azabieyclo[4.1.0]heptane derivatives with nitric oxide synthase inhibitory activity
Del Villar, Irene Suarez,Gradillas, Ana,Gomez-Ovalies, Angel,Martinez-Murillo, Ricardo,Martinez, Alfredo,Perez-Castells, Javier
body text, p. 1222 - 1223 (2009/12/01)
Synthesis of new bicyclic structures containing cyclopro-panes, related to selective iNOS inhibitor ONO-1714, is described. We have evaluated the effect of the compounds obtained on the production of nitric oxide in lipopolysaccharide and inter-feron-gamm
Biomimetic Synthesis of Quinolizidine Alkaloids
Wanner, Martin J.,Koomen, Gerrit-Jan
, p. 8431 - 8442 (2007/10/02)
Quinolizidine alkaloids are synthesized from glutarimide ylides via a piperidine ring transformation that is based on the lupinine biosynthesis.A short enantioselective bispiperidine synthesis using R-phenylglycinol as a chiral precursor is described.Key
