138480-41-8

Upstream product

• 110-94-1 1,5-pentanedioic acid 
• 104-94-9 4-methoxy-aniline 
• 108-55-4 glutaric anhydride, 
• 60-29-7 diethyl ether 
• 10026-13-8 phosphorus pentachloride 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 138480-32-7 N-4-methoxyphenyl-6-hydroxy-2-piperidone 
• 104-94-9 4-methoxy-aniline 
• 1257251-00-5 1-(4-methoxyphenyl)-3,4-dihydropyridin-2(1H)-one 
• 138480-33-8 5-[2,6-Dioxo-piperidin-(3E)-ylidene]-pentanoic acid (4-methoxy-phenyl)-amide 
• 138480-49-6 5-[2,6-Dioxo-piperidin-(3Z)-ylidene]-pentanoic acid (4-methoxy-phenyl)-amide 
• 91645-20-4 δ-Hydroxy-valer-N-, 5-Hydroxy-N-<4-methoxy-phenyl>-valeramid 

Relevant academic research and scientific papers

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Synthesis of some biologically active 2,6-dichloro-1-(N-substituted phenyl)-1,4-dihydropyridine-3,5-Dicarbaldehydes using vilsmeier-haack reaction and their applications

Various 2,6-dichloro-1-(N-substituted phenyl)-1,4-dihydropyridine-3,5- dicarbaldehydes were synthesized in two steps using moderate conditions and 3,5-diformyl groups were transformed into different functionalities. The synthesized compounds were screened

Synthesis of 2-azabicyclo[4.1.0]heptanes through stereoselective cyclopropanation reactions

Unsaturated δ-lactams are cyclopropanated with the aid of diazo compound decomposition catalysed by metal complexes. A study of the reaction conditions, stereochemical outcome and group protection is reported. The resulting bicyclic products are related to bioactive compounds. Transformation into thiolactams facilitates the separation of the different isomers obtained and the removal of the protecting group. The cyclopropanation reaction works with diverse diazo compounds. Unsaturated δ-lactams are cyclopropanated with the aid of diazo compound decomposition catalysed by metal complexes. A study of the reaction conditions, stereochemical outcome and group protection isreported. Transformation into thiolactams assists in separation of the different isomers obtained and removal of the protecting group.

Cyclopropanation reactions for the synthesis of 2-azabieyclo[4.1.0]heptane derivatives with nitric oxide synthase inhibitory activity

Synthesis of new bicyclic structures containing cyclopro-panes, related to selective iNOS inhibitor ONO-1714, is described. We have evaluated the effect of the compounds obtained on the production of nitric oxide in lipopolysaccharide and inter-feron-gamm

Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides

This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classical models of pain in mice. These compounds show high activity, being more active than acetyl salycilic aci

The Function of Sodium Acetate in Cyclodehydration of Glutaranilic Acids

The rate of cyclodehydration of glutaranilic acids in acetic anhydride in the presence of sodium acetate affording N-arylglutarimides was studied. The reaction was established to proceed irreversible with quantitative yield in keeping with fitst order kin

Biomimetic Synthesis of Quinolizidine Alkaloids

Quinolizidine alkaloids are synthesized from glutarimide ylides via a piperidine ring transformation that is based on the lupinine biosynthesis.A short enantioselective bispiperidine synthesis using R-phenylglycinol as a chiral precursor is described.Key