138481-22-8Relevant articles and documents
Enantiocontrolled synthesis of the antifungal β-lactam (2R,5S)-2-(hydroxymethyl)clavam
Konosu,Oida
, p. 2212 - 2215 (2007/10/02)
The antifungal β-lactam (2R,5S)-2-(hydroxymethyl)clavam was synthesized in a convergent and stereocontrolled manner from methyl 6-phthalimidopenicillanate and 2,3-O-isopropylidene-(R)-glyceraldehyde. Convenient methods of acetonide cleavage and phthalimide deblocking are also described.