66036-39-3Relevant academic research and scientific papers
3-SUBSTITUTED-4-OXA-1-AZABICYCLO[3,2,0]HEPTAN-7-ONE AS CYSTEINE PROTEASE INHIBITORS
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, (2008/06/13)
The use of certain 3-substituted-4-oxa-1-azabicyclo[3,2,0] heptan-7-one derivatives of general formula I, STR1 or physiologically acceptable salts thereof or isomers thereof, as active ingredients for the preparation of pharmaceutical composition and trea
Enantiocontrolled synthesis of the antifungal β-lactam (2R,5S)-2-(hydroxymethyl)clavam
Konosu,Oida
, p. 2212 - 2215 (2007/10/02)
The antifungal β-lactam (2R,5S)-2-(hydroxymethyl)clavam was synthesized in a convergent and stereocontrolled manner from methyl 6-phthalimidopenicillanate and 2,3-O-isopropylidene-(R)-glyceraldehyde. Convenient methods of acetonide cleavage and phthalimide deblocking are also described.
Total Synthesis of &β-Lactamase Inhibitors based on the 4-Oxa-1-azabicycloheptan-7-one Ring System
Bentley, Peter H.,Hunt, Eric
, p. 2222 - 2227 (2007/10/02)
4-(2-Bromoethoxy)azetidin-2-one (4), 4-(1,3-dibromoisopropoxy)azetidin-2-one (5), 4-(1-benzyloxy-3-chloroisopropoxy)azetidin-2-one (6), 4-azetidin-2-one (7), and 4-azetidin-2-one (8) have been s
