1384846-98-3

Basic information

• Product Name: 2-methylnaphtho[1,2-d]oxazole-9-carboxylic acid
• Synonyms: 2-methylnaphtho[1,2-d]oxazole-9-carboxylic acid
• CAS NO: 1384846-98-3
• Molecular Weight: 227.219
• Mol File: 1384846-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methylnaphtho[1,2-d]oxazole-9-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylnaphtho[1,2-d]oxazole-9-carboxylic acid(1384846-98-3)
• EPA Substance Registry System: 2-methylnaphtho[1,2-d]oxazole-9-carboxylic acid(1384846-98-3)

Safety Data

• Hazardous Substances Data: 1384846-98-3(Hazardous Substances Data)

Upstream product

• 2216-13-9 8-nitro-1-naphthalenecarboxylic acid 
• 64-19-7 acetic acid 

Relevant articles and documents

Aristoxazole analogues. Conversion of 8-Nitro-1-naphthoic acid to 2-Methylnaphtho[1,2- d ]oxazole-9-carboxylic acid: Comments on the chemical mechanism of formation of DNA adducts by the aristolochic acids

2-Methylnaphtho[1,2-d]oxazole-9-carboxylic acid was obtained by reduction of 8-nitro-1-naphthoic acid with zinc-acetic acid. This naphthoxazole is a condensation product between an 8-nitro-1-naphthoic acid reduction intermediate and acetic acid and is a lower homologue of aristoxazole, a similar condensation product of aristolochic acid I with acetic acid that was previously reported. Both oxazoles are believed to arise via a common nitrenium/carbocation ion mechanism that is likely related to that which leads to aristolochic acid-DNA-adducts.