1384955-72-9

Basic information

• Product Name: C₂₆H₂₄O₆
• CAS NO: 1384955-72-9
• Molecular Weight: 432.473
• Mol File: 1384955-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₄O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₄O₆(1384955-72-9)
• EPA Substance Registry System: C₂₆H₂₄O₆(1384955-72-9)

Safety Data

• Hazardous Substances Data: 1384955-72-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 140-10-3 (E)-3-phenylacrylic acid 
• 517-89-5 shikonin 

Relevant articles and documents

Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives

Inducing apoptosis is an important and promising therapeutic approach to overcome cancer. Here, we described a series of novel synthesized compounds, cinnamic acyl shikonin derivatives (1b-19b), which were synthesized starting from shikonin and cinnamic acids, which exhibit anticancer activity via inducing apoptosis in vitro. Our flow cytometry results showed that compound 8b((E)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent -3-enyl-3-(3-(trifluoromethyl) phenyl)acrylate) (IC50=0.69, 0.65, 1.62 μm for human SW872-s, A875 and A549 cell lines, respectively) exhibited conspicuous anticancer activities and has low cell toxicity in vitro. Therefore, we considered that compound 8b is potentially to be a candidate of anticancer agent. The proliferation inhibitory effect of compound 8b was associated with its apoptosis-inducing effect by activating caspase-3, caspase-7, caspase-9, and PARP. When the level of cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, and cleaved PARP are rise, apoptosis of cancer cells will be induced.