1384956-53-9

Upstream product

• 50-01-1 guanidine hydrochloride 
• 98466-44-5 methyl 2-(3',4'-dimethoxyphenyl)-2-cyanoethanoate 

Downstream Products

• 1384956-54-0 2,4-diamino-5-(3',4'-dihydroxyphenyl)-6-pyrimidinone 
• 1009598-96-2 6-amino-5-(3,4-dihydroxyphenyl)pyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

Syntheses and electrochemical properties of novel aminopyrimidinone derivatives as a new class of abasic-site binders

We describe syntheses and electrochemical properties of a new class of aminopyrimidinone derivatives: 2-amino-4-(3',4'-dimethoxyphenyl)-6-pyrimidinone, 2-amino-4-(3',4'-dihydroxyphenyl)-6-pyrimidinone, 2,4-diamino-5-(3',4'- dimethoxyphenyl)-6-pyrimidinone, 2,4-diamino-5-(3',4'-dihydroxyphenyl)-6- pyrimidinone, and 4-amino-5-(3',4'-dihydroxyphenyl)-2,6-pyrimidinione, three of which possess a catechol unit as an oxidation-active moiety for developing electrochemically detectable abasic-site binders. These compounds were synthesized via a pyrimidine-ring forming reaction with guanidine. Cyclic voltammetry measurements revealed that the catechol-bearing derivatives showed oxidation potentials lower than that of DNA, indicating that they satisfied the requirements for the purpose. Graphical Abstract: [Figure not available: see fulltext.]