1384959-19-6

Basic information

• Product Name: C₃₀H₂₅N₃O₃
• Synonyms: C₃₀H₂₅N₃O₃
• CAS NO: 1384959-19-6
• Molecular Weight: 475.547
• Mol File: 1384959-19-6.mol

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₅N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₅N₃O₃(1384959-19-6)
• EPA Substance Registry System: C₃₀H₂₅N₃O₃(1384959-19-6)

Safety Data

• Hazardous Substances Data: 1384959-19-6(Hazardous Substances Data)

Upstream product

• 15482-54-9 p-(2-oxopropyl)-benzoic acid 
• 1384959-15-2 1-[4-(2-thioxo-thiazolidine-3-carbonyl)-phenyl]-propan-2-one 
• 154310-42-6 [3-(acridin-9-ylamino)-5-aminophenyl]methanol 

Relevant articles and documents

Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation

Acridines are potent DNA-intercalating anticancer agents with high in vivo anticancer effectiveness, but also severe side effects. We synthesized five 9-anilinoacridine-type drugs and their conjugates with biocompatible water-soluble hydrazide polymer carrier. All of the synthesized acridine drugs retained their in vitro antiproliferative properties. Their polymer conjugates were sufficiently stable at pH 7.4 (model of pH in blood plasma) while releasing free drugs at pH 5.0 (model of pH in endosomes). After internalization of the conjugates, the free drugs were released and are visible in cell nuclei by fluorescence microscopy. Their intercalation ability was proven using a competitive ethidium bromide displacement assay.