15482-54-9

Usage

Uses

Used in Organic Synthesis:
(4-Carboxyphenyl)acetone is used as a building block in organic synthesis for its versatile chemical properties. It serves as a key intermediate in the production of a wide range of organic compounds.
Used in Pharmaceutical Synthesis:
(4-Carboxyphenyl)acetone is used as a starting material or intermediate in the synthesis of pharmaceuticals. Its unique structure and functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
(4-Carboxyphenyl)acetone is also utilized in the synthesis of agrochemicals, such as pesticides and herbicides. Its chemical properties make it a valuable component in the creation of effective and environmentally friendly agricultural products.

InChI:InChI=1/C10H10O3/c1-7(11)6-8-2-4-9(5-3-8)10(12)13/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 6232-88-8 4-bromomethylbenzoic Acid 
• 75-36-5 acetyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 67-64-1 acetone 
• 5006-04-2 1-(4-carboxyphenyl)-2-nitroprop-1-ene 
• 7439-89-6 iron 
• 619-58-9 4-iodobenzoic acid 
• 123-54-6 acetylacetone 
• 58949-75-0 4-(2-oxopropyl)benzonitrile 

Downstream Products

• 74733-17-8 4-acetonylbenzoyl chloride 
• 22744-50-9 1-(4-carbomethoxyphenyl)-propan-2-one 
• 1384959-19-6 C₃₀H₂₅N₃O₃ 
• 1384959-15-2 1-[4-(2-thioxo-thiazolidine-3-carbonyl)-phenyl]-propan-2-one 

Relevant academic research and scientific papers

Aryl C-F bond functionalization preparation method

The invention relates to the technical field of organic compound synthesis, in particular to an aryl C-F bond functionalization preparation method. A fluorobenzene compound and a nucleophilic reagent react under the action of a composite catalyst, wherein the composite catalyst is formed by mixing a visible light catalyst and a metal catalyst. The photocatalyst is adopted, the reaction process is safe and controllable, and operation in the preparation and production process is simplified; a purple LED is used as a reaction energy source and is green and environment-friendly, the energy utilization rate is high, and conversion from light energy to chemical energy can be efficiently realized; in the reaction, a simple nucleophilic reagent is used for attacking free radical cation species generated under a visible light catalysis condition, so that a target product with an extremely wide range is efficiently and greenly prepared; the operation steps are simplified, and the reaction route is shortened; and moreover, the forward reaction rate is high, and the production efficiency is remarkably improved.

Copper catalyzed arylation/C-C bond activation: An approach toward α-aryl ketones

An efficient arylation/C-C activation process was discovered. -Diketones with aryl halides (aryl iodides and aryl bromides) could undergo reaction smoothly in the presence of Cu(I) or Cu(II) salts in DMSO using K3 PO4 3H2 O without ligands. The role of H2 O was unprecedented, which assisted the C-C activation. Various -aryl ketones could be efficiently synthesized by this novel method. In situ monitoring of the formation of KOAc and experimentation relating to "a classic diagnostic technique for the participation of radical anion intermediates" revealed the preliminary mechanistic information for the reaction. This method is simple, general, and practical which complemented the classic method for the rapid construction of C-C bonds to a carbonyl moiety.

Metallic Nickel-Mediated Synthesis of Ketones by the Reaction of Benzylic, Allylic, Vinylic, and Pentafluorophenyl Halides with Acid Halides

Metallic nickel was investigated as a convenient coupling reagent for the synthesis of ketones by the reaction of benzylic, allylic, vinylic, and pentafluorophenyl halides with acid halides at 85 deg C in glyme.A variety of benzylic ketones with functional groups including halogen, cyano, methoxycarbonyl, and hydroxycarbonyl groups were prepared in good yields by this method.The reaction was demonstrated to proceed via organonickel halide intermediates formed by the smooth oxidative addition of benzylic and acyl halides to metallic nickel, which were trapped with electron-deficient olefins. (?-Allyl)nickel halides, prepared in situ at 85 deg C from allylic halides and the nickel, also worked for the preparation of ketones.Vinylic and pentafluorophenyl halides but not alkyl halides reacted with acid halides to give the corresponding ketones in moderate yields.

2(1H)-pyridinone derivatives, their preparation and pharmaceutical compositions containing them

The compounds of formula I STR1 wherein R, R1 and R2 have various significances, are useful as agents against heart insufficiency.

Secondary amines, their preparation and use in pharmaceutical compositions

The compounds of the formula (II): STR1 and their pharmaceutically acceptable salts wherein R1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R3 is a hydrogen or chlorine atom or a hydroxyl group; R4 is a carboxylic acid group or a salt, ester or amide thereof; R5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or antihyperglycaemic activity.