1384970-90-4

Basic information

• Product Name: 2-(4-imino-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylthio)-1-(pyrrolidin-1-yl)ethanone
• Synonyms: 2-(4-imino-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylthio)-1-(pyrrolidin-1-yl)ethanone
• CAS NO: 1384970-90-4
• Molecular Weight: 368.462
• Mol File: 1384970-90-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-imino-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylthio)-1-(pyrrolidin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-imino-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylthio)-1-(pyrrolidin-1-yl)ethanone(1384970-90-4)
• EPA Substance Registry System: 2-(4-imino-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylthio)-1-(pyrrolidin-1-yl)ethanone(1384970-90-4)

Safety Data

• Hazardous Substances Data: 1384970-90-4(Hazardous Substances Data)

Upstream product

• 90892-09-4 bromoacetopyrrolidine 
• 1384972-99-9 4-imino-3-methyl-5-phenyl-4,5-dihydro-1H-pyrazolo-[3,4-d]pyrimidine-6(7H)-thione 
• 5453-07-6 5-amino-3-methyl-1H-pyrazole-4-carbonitrile 
• 103-72-0 phenyl isothiocyanate 

Relevant articles and documents

PYRAZOLOPYRIMIDINE DERIVATIVES AND USES AS ANTICANCER AGENTS

Novel compounds having a fused pyrazolopyrimidine derivatives and related fused ring systems are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Pharmaceutical compositions, and methods of using these compounds and compositions to treat cancer and other diseases related to the dysregulation of kinase (such as Aurora A, Aurora B, Aurora C, cMet, JAK2, ROS1, but not limited to) pathways are disclosed. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.