1384980-52-2

Upstream product

• 76456-06-9 imino(methyl)(pyridin-2-yl)-λ⁶-sulfanone 
• 2890-61-1 1-methyl-1-cyclohexancarboxylic acid chloride 
• 1123-25-7 1-methyl-1-cyclohexanecarboxylic acid 
• 1384980-70-4 N-[3-acetoxy-2-benzyl-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine 
• 1384980-51-1 N-[2,2-dimethyl-3-phenylpropanoyl]-S-methyl-S-2-pyridylsulfoximine 
• 951787-81-8 N-(4-nitrobenzenesulfonyl) methyl (2-pyridinyl) sulfoximine 
• 21948-75-4 2-methylsulfinylpyridine 
• 18438-38-5 2-methylsulfanyl-pyridine 
• 2637-34-5 2-Sulfanylpyridine 

Downstream Products

• 1384980-71-5 N-[1-(acetoxymethyl)cyclohexanecarboxyl]-S-methyl-S-2-pyridylsulfoximine 

Relevant academic research and scientific papers

Sulfoximine assisted Pd(II)-catalyzed bromination and chlorination of primary β-C(sp3)-H bond

S-Methyl-S-2-pyridyl-sulfoximine (MPyS) directed bromination and chlorination of the 1°-β-C(sp3)-H bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst. The sequential halogenation and acetoxylation of α-dimethyl MPyS-N-amides constructs highly functionalized α-trisubstituted aliphatic acid derivatives. The MPyS directing group is cleaved from the halogenated products and recovered. (Chemical Equation Presented).

Pd(II)-catalyzed primary-C(sp3)-H acyloxylation at room temperature

With the aid of a novel S-methyl-S-2-pyridyl-sulfoximine (MPyS) directing group (DG), the unactivated primary β-C(sp3)-H bond of MPyS-N-amides oxidizes at room temperature. The catalytic conditions are applicable to the diacetoxylation of primary β,β′-C(sp 3)-H bonds, and the carboxylic acid solvent is pivotal in the formation of the C-O bond. The MPyS-DG cleaves from the oxidation products and is recovered. This method provides convenient access to α,α′- disubstituted-β-hydroxycarboxylic acids.