13850-14-1Relevant academic research and scientific papers
THE CYTOTOXIC PRINCIPLES OF HYPTYS CAPITATA AND THE STRUCTURES OF THE NEW TRITERPENES HYPTATIC ACID-A AND -B
Yamagishi, Takashi,Zhang, De-Cheng,Chang, Jer-Jang,McPhail, Donald R.,McPhail, Andrew T.,Lee, Kuo-Hsiung
, p. 3213 - 3216 (1988)
Bioassay-directed franctionation of a methanolic extract of Hyptis capitata has led to the isolation and characterization of five triterpene acids which include the new hyptatic acids-A and -B in addition to the known 2α-hydroxyursulic acid, tormentic acid and maslinic acid.Spectral data in conjuction with X-ray analysis of the methanol solvate of hyptatic acid-A established the structures of these compounds.Hyptatic acid-A and 2α-hydroxyursolic acid demonstrated significant in vitro cytotoxicity in human colon HCT-8 tumour cells.Key Word Index - Hyptis capitata; Labiatae; cytotoxicity; triterpenes; hyptatic acid-A; hyptatic acid-B; tomentic acid; maslinic acid; 2α-hydroxyursolic acid.
Tormentic acid derivatives: Synthesis and apoptotic activity
Csuk, René,Siewert, Bianka,Dressel, Christian,Sch?fer, Renate
, p. 237 - 245 (2013/01/15)
Several derivatives of tormentic acid have been prepared and tested for their antitumor activity. The dichloroacetate 14 is an excellent antitumor active agent acting by an apoptose inducing pathway as demonstrated by OA/PI staining, DNA laddering experiments as well as by an annexin V binding assay.
