THE CYTOTOXIC PRINCIPLES OF HYPTYS CAPITATA AND THE STRUCTURES OF THE NEW TRITERPENES HYPTATIC ACID-A AND -B

Article abstract of DOI:10.1016/0031-9422(88)80028-1

Bioassay-directed franctionation of a methanolic extract of Hyptis capitata has led to the isolation and characterization of five triterpene acids which include the new hyptatic acids-A and -B in addition to the known 2α-hydroxyursulic acid, tormentic acid and maslinic acid.Spectral data in conjuction with X-ray analysis of the methanol solvate of hyptatic acid-A established the structures of these compounds.Hyptatic acid-A and 2α-hydroxyursolic acid demonstrated significant in vitro cytotoxicity in human colon HCT-8 tumour cells.Key Word Index - Hyptis capitata; Labiatae; cytotoxicity; triterpenes; hyptatic acid-A; hyptatic acid-B; tomentic acid; maslinic acid; 2α-hydroxyursolic acid.