1385011-82-4

Basic information

• Product Name: C₃₁H₄₈N₂O₅
• Synonyms: C₃₁H₄₈N₂O₅
• CAS NO: 1385011-82-4
• Molecular Weight: 528.733
• Mol File: 1385011-82-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₁H₄₈N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₄₈N₂O₅(1385011-82-4)
• EPA Substance Registry System: C₃₁H₄₈N₂O₅(1385011-82-4)

Safety Data

• Hazardous Substances Data: 1385011-82-4(Hazardous Substances Data)

Upstream product

• 465-20-3 bufalin 

Relevant articles and documents

Synthesis and biological evaluation of bufalin-3-yl nitrogen-containing-carbamate derivatives as anticancer agents

A series of bufalin-3-yl nitrogen-containing-carbamate derivatives 3 were designed, synthesized, and evaluated for their proliferation inhibition activities against human cervical epithelial adenocarcinoma (HeLa) cell line. The structure-activity relationships (SARs) of this new series are described in this paper. Cytotoxicity data revealed that the C3 moiety had an important influence on cytotoxic activity. Compound 3i-HCl exhibited significant in vitro antiproliferative activity against the ten tested tumor cell lines, with IC50 values ranging from 0.30 to 1.09 nM. Furthermore, 3i-HCl can significantly inhibit tumor growth by 100% at the dose 2 mg/kg by iv, or 4 mg/kg by ig.