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3-Epibufalin is a steroidal alkaloid derived from the skin secretions of the Colorado River toad (Incilius alvarius) and is structurally similar to bufalin, a compound found in the Chinese toad (Bufo gargarizans). It exhibits potent cardiotonic and anti-cancer properties, with the ability to inhibit the activity of Na+/K+-ATPase, a key enzyme in cellular energy production. This inhibition leads to an increase in intracellular calcium levels, which can enhance the contractile force of heart muscles, making it a potential treatment for heart failure. Additionally, 3-epibufalin has shown promise in cancer research due to its ability to disrupt cancer cell metabolism and induce apoptosis, or programmed cell death. However, it is important to note that 3-epibufalin is a potent compound and requires careful handling and further research to fully understand its therapeutic potential and safety profile.

465-20-3

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465-20-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 465-20-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 5 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 465-20:
(5*4)+(4*6)+(3*5)+(2*2)+(1*0)=63
63 % 10 = 3
So 465-20-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17-,18-,19?,20?,22+,23-,24+/m1/s1

465-20-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one

1.2 Other means of identification

Product number -
Other names 3-epibufalin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:465-20-3 SDS

465-20-3Relevant academic research and scientific papers

Unified Total Synthesis of Five Bufadienolides

Hagiwara, Koichi,Inoue, Masayuki,Itoh, Hiroaki,Shimizu, Shinsuke

, (2020/11/13)

We report a unified total synthesis of five bufadienolides: bufalin (1), bufogenin B (2), bufotalin (3), vulgarobufotoxin (4), and 3-(N-succinyl argininyl) bufotalin (5). After the steroidal ABCD ring 8 was produced, the D ring was cross-coupled with a 2-pyrone moiety and stereoselectively epoxidized to generate 6. TMSOTf promoted a stereospecific 1,2-hydride shift from 6 to establish the β-oriented 2-pyrone of 19. Functional group manipulations from 19 furnished 1-5, which potently inhibited cancer cell growth.

Probing the stereoselectivity of OleD-catalyzed glycosylation of cardiotonic steroids?

Zhu, Xue-Lin,Wen, Chao,Ye, Qing-Mei,Xu, Wei,Zou, Deng-Lang,Liang, Guang-Ping,Zhang, Fan,Chen, Wan-Na,Jiang, Ren-Wang

, p. 5071 - 5078 (2018/02/09)

The glycosyltransferase OleD variant as a catalyst for the glycosylation of four pairs of epimers of cardiotonic steroids (CTS) are assessed. The results of this study demonstrated that the OleD-catalyze glycosylation of CTS is significantly influenced by

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