1385032-99-4Relevant academic research and scientific papers
Use of the α-amination reaction for the synthesis of pyrazole derivatives containing carbo- and heterocyclic substituents on the nitrogen atom
Utkina,Kurkin,Yurovskaya
, p. 327 - 333 (2012)
A method has been developed for the synthesis of pyrazoles with carbo- and heterocyclic substituents on the nitrogen atom based on the α-amination reaction of carbo- and heterocyclic ketones, using azodicarboxylate-L-proline system with subsequent interaction with malonodialdehyde tetramethylacetal. In the case of carbocyclic ketones and tetrahydro-γ-pyranone, the reaction occurs stereoselectively to give chiral hydrazines and pyrazoles. With derivatives of piperidin-4-one, α-amination is accompanied by racemization.
