1385050-41-8

Upstream product

• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 87-42-3 6-chloropurine 
• 288-88-0 1,2,4-Triazole 
• 112089-33-5 6-chloro-9-(2-chlorophenylmethyl)-9H-purine 

Relevant academic research and scientific papers

Synthesis of C6-azolyl purine nucleosides via C-N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles under catalyst- and solvent-free conditions

C6-azolyl purine nucleoside products are prepared in high yields under solvent- and catalyst-free conditions via C-N coupling reaction of unprotected 6-chloropurine nucleosides and N-heterocycles, providing a unifying, simple and environmentally friendly complement to the available methods. The Royal Society of Chemistry 2012.

Synthesis and anticonvulsant activity of novel purine derivatives

A series of new purines containing triazole and other heterocycle substituents was synthesized and evaluated for their preliminary anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and rotarod neurotoxicity (TOX) tests. Among the compounds studied, 9-decyl-6-(1H-1,2,4-triazol-1-yl)-9H-purine (5e) was the most potent compound, with a median effective dose of 23.4 mg/kg and a high protective index of more than 25.6 after intraperitoneal administration in mice. Compound 5e showed significant oral activity against MESinduced seizures in mice, with an ED50 of 39.4 mg/kg and a PI above 31.6. These results demonstrate that compound 5e possesses better anticonvulsant activity and is safer than the commercially available drugs carbamazepine and valproate in MES, scPTZ and TOX models.