112089-33-5

Basic information

• Product Name: 9H-Purine, 6-chloro-9-[(2-chlorophenyl)methyl]-
• CAS NO: 112089-33-5
• Molecular Formula: C12H8Cl2N4
• Molecular Weight: 279.128
• Mol File: 112089-33-5.mol

Chemical Properties

• CAS DataBase Reference: 9H-Purine, 6-chloro-9-[(2-chlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Purine, 6-chloro-9-[(2-chlorophenyl)methyl]-(112089-33-5)
• EPA Substance Registry System: 9H-Purine, 6-chloro-9-[(2-chlorophenyl)methyl]-(112089-33-5)

Safety Data

• Hazardous Substances Data: 112089-33-5(Hazardous Substances Data)

Upstream product

• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 87-42-3 6-chloro-7H-purine 
• 87-42-3 6-chloropurine 
• 95-49-8 2-methylchlorobenzene 

Downstream Products

• 1590360-52-3 C₁₅H₁₂ClN₅ 
• 1590360-64-7 3-(2-chlorobenzyl)-7-methyl-3H-imidazo[2,1-i]purine 
• 1510826-46-6 2-(9-(2-chlorobenzyl)-9H-purin-6-yl)-N,N-dibenzyl-4-phenylbutanamide 
• 1385050-41-8 9-(2-chlorobenzyl)-6-(1H-1,2,4-triazol-1-yl)-9H-purine 
• 1356160-61-6 6-(benzylthio)-9-(2-chlorobenzyl)-9H-purine 
• 1356160-48-9 C₁₃H₁₁ClN₆S*ClH 
• 1346993-49-4 9-(2-chlorobenzyl)-6-phenyl-9H-purine 
• 1262281-29-7 9-(2-chlorobenzyl)-6-phenoxy-9H-purine 
• 1241556-24-0 4-(9-(2-chlorobenzyl)-9H-purin-6-yl)naphthalen-1-ol 
• 1181816-28-3 9-(2-chlorophenylmethyl)-6-[N,N-bis(2-hydroxyethyl)amino]purine 
• 1142812-48-3 9-(2-chlorobenzyl)-6-methyl-9H-purine 
• 1142812-43-8 ethyl 2-(9-(2-chlorobenzyl)-9H-purin-6-yl)acetate 
• 1142812-35-8 ethyl 2-(9-(2-chlorobenzyl)-9H-purin-6-yl)acetoacetate 
• 112089-23-3 6-(Dimethylamino)-9-(2-chlorobenzyl)-9H-purine 

Relevant articles and documents

C-H amination of purine derivatives via radical oxidative coupling

An oxidative coupling reaction between purines and alkyl ethers/benzyl compounds was developed to synthesize a series of N9 alkylated purine derivatives using n-Bu4NI as a catalyst and t-BuOOH as an oxidant. This protocol uses commercially available, inexpensive catalysts and oxidants and has a wide range of substrates with a simple operation.

The Convenient Synthesis of Unsaturated Nucleoside Analogues in Water under Microwave Irradiation

A convenient method for the regioselective synthesis of unsaturated nucleoside analogs in water under microwave irradiation was developed. All pyrimidine and purine nucleoside derivatives were exclusively alkylated at N1 and N9 respectively in good to excellent yields. In addition, this system could tolerate a broad range of functional groups, such as chloro, bromo, iodo, alkyl, amino, and hydroxyl groups. More importantly, the reaction scale could be enlarged to 50 mmol which made this route attractive for industrial application.

Synthesis, biological activity, and SAR of antimycobacterial 9-aryl-, 9-arylsulfonyl-, and 9-benzyl-6-(2-furyl)purines

9-Aryl-, 9-arylsulfonyl- and 9-benzyl-6-(2-furyl)purines were synthesized by N-alkylation or N-arylation of the purine followed by Stille coupling to introduce the furyl substituent in the 6-position and the compounds screened for activity against Mycobac

9-(2-fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents

Several substituted aryl and 6-alkylamino analogues of the anticonvulsant purine 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Derivatives with a second fluoro substituent in the 5- or 6-position of the aryl moiety were very active with ip ED50's that ranged from 2 to 4 mg/kg. Congeners in which the purine 6-substituent was varied among a number of alkylamino groups possessed potent activity against MES that was comparable to or several times better than phenytoin.