138508-48-2

Upstream product

• 93711-81-0 (4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 138508-46-0 (2S,4S)-4-Mercapto-2-{4-[2-(4-nitro-benzyloxycarbonyloxy)-ethyl]-[1,4]diazepane-1-carbonyl}-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 104873-15-6 4-nitrobenzyl (4R,5R,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]-heptane-2-carboxylate 
• 147082-06-2 (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid 
• 138508-07-3 (2S,4S)-4-(4-methoxybenzylthio)-2-[4-[2-(4-nitrobenzyloxycarbonyloxy)ethyl]-1-homopiperazinylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 1β-methylcarbapenems with quaternary ammonium side chains

The synthesis and antibacterial activity of 1β-methylcarbapenems with quaternary ammonium groups at the C-2 position have been studied. Two types of new carbapenem derivatives have been synthesized. These 1β-methylcarbapenems, one type having a (2S,4S)-2-[1,1-dimethyl-2-(1-piperazinyl)carbonyl]pyrrolidinio-4-ylthio group and the other type having a (2S,4S)-2-(4-carbamoylmethyl-4-methylhomopiperazinio-1-ylcarbon-yl)pyrrolidin-4 -ylthio group, show potent and well balanced antibacterial activity as well as high stability against dehydropeptidase-I. The in vivo potency of these two carbapenems was compared with that of meropenem. The structure-activity relationships leading to these carbapenems are also described.

Carbapenem derivatives having antibiotic activity, their preparation and their use

Carbapenem compounds of formula (I): STR1 in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R1 is hydrogen or methyl; R2 is hydrogen or alkyl; R3 is hydrogen or a negative io