1385096-46-7

Basic information

• Product Name: C₁₃H₁₁F₃N₂O₂S
• CAS NO: 1385096-46-7
• Molecular Weight: 316.304
• Mol File: 1385096-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₁F₃N₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₁F₃N₂O₂S(1385096-46-7)
• EPA Substance Registry System: C₁₃H₁₁F₃N₂O₂S(1385096-46-7)

Safety Data

• Hazardous Substances Data: 1385096-46-7(Hazardous Substances Data)

Upstream product

• 1385096-44-5 C₁₃H₁₃F₃N₂O₂S 
• 98-59-9 p-toluenesulfonyl chloride 
• 40949-56-2 N-(p-toluenesulphonylimino)pyridinium ylide 

Relevant articles and documents

Synthesis of 7-trifluoromethylpyrazolo[1,5-a]pyridinedicarboxylate

Two syntheses of 7-trifluoromethylpyrazolo[1,5-a]pyridine dicarboxylate have been described. Approach A utilizes a nucleophilic addition of a trifluoromethyl group to N-p-toluenesulfonyliminopyridinium ylide followed by aromatization and subsequent cycloaddition with diethyl acetylenedicarboxylate to give 1b in modest yield. Approach B involves a selective zincation of pyrazolopyridine dicarboxylate at the C7 position with (TMP) 2Zn·2LiCl·2MgCl2 followed by iodination and trifluoromethylation to give 1b in good yield. The process in approach B has been successfully demonstrated on scale.