138514-31-5

Basic information

• Product Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-7-[(phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-
• CAS NO: 138514-31-5
• Molecular Formula: C29H27N3O5S2
• Molecular Weight: 561.682
• Mol File: 138514-31-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-7-[(phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-7-[(phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-(138514-31-5)
• EPA Substance Registry System: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-7-[(phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-(138514-31-5)

Safety Data

• Hazardous Substances Data: 138514-31-5(Hazardous Substances Data)

Upstream product

• 82294-70-0 4-methyl-1,3-thiazole-5-carbaldehyde 
• 119636-62-3 [(6R,7R)-2-(4-Methoxy-benzyloxycarbonyl)-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl]-triphenyl-phosphonium; iodide 
• 104146-10-3 (6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 

Downstream Products

• 119608-99-0 p-Methoxybenzyl 7-amino-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 155723-02-7 (6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 823792-22-9 7-phenylacetamido-3-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid 
• 104146-53-4 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt 
• 138450-73-4 p-Methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 117467-28-4 cefditoren pivoxil 

Relevant articles and documents

Cefditoren pivoxil intermediate preparation method

The invention discloses a cefditoren pivoxil intermediate preparation method. The method includes steps: 1) in existence of sodium iodide, allowing contact reaction of GCLE and triphenylphosphine in a first mixed solvent, cooling to 8-10 DEG C, adding sod

AN IMPROVED PROCESS FOR THE PREPARATION OF CEFDITOREN

The present invention relates to an improved process for the preparation of Cefditoren of formula (I), the said process comprising the steps of: i) converting the compound of formula (II) to a compound of the formula (III) using TPP and sodium iodide in the presence of THF, water, and base; ii) reacting the compound of formula (III) with 4-methyl-5-formyl-thiazole to produce a compound of formula (IV); iii) deesterifying the compound of the formula (IV) to yield compound of formula (V); iv) converting the compound of formula (V) to compound of formula (VI) in the presence of a base and solvent; v) converting the compound of formula (VI) into compound of formula (VII) by enzymatic hydrolysis; and vi) reacting compound of formula (VII) with compound of formula (VIII) in the presence of solvent and base to produce compound of formula (I).