823792-22-9Relevant academic research and scientific papers
3-ALKENYLCEPHEM COMPOUNDS AND PROCESS FOR PRODUCTION THEREOF
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Page/Page column 11, (2008/06/13)
A 3-alkenylcephem compound of the formula (1) wherein R 1 is benzyl or phenoxymethyl, R 2 , R 3 and R 4 are alike or different and are each a hydrogen atom, C 1-10 alkyl, C 4-8 cycloalkyl or aryl C 1-3 alkyl substituted or unsubstituted with C 1-4 alkyl, R 2 and R 3 , when taken together, form a group -(CH 2 ) 1 X m (CH 2 ) n - substituted or unsubstituted with C 1-4 alkyl at an optional position, X is an oxygen atom or group -N(R 5 )-, 1 is 0 to 3, m is 0 or 1, n is an integer of 2 to 4, R 5 is a hydrogen atom or C 1-4 alkyl.
AN IMPROVED PROCESS FOR THE PREPARATION OF CEFDITOREN
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Page 6, (2010/02/10)
The present invention relates to an improved process for the preparation of Cefditoren of formula (I), the said process comprising the steps of: i) converting the compound of formula (II) to a compound of the formula (III) using TPP and sodium iodide in the presence of THF, water, and base; ii) reacting the compound of formula (III) with 4-methyl-5-formyl-thiazole to produce a compound of formula (IV); iii) deesterifying the compound of the formula (IV) to yield compound of formula (V); iv) converting the compound of formula (V) to compound of formula (VI) in the presence of a base and solvent; v) converting the compound of formula (VI) into compound of formula (VII) by enzymatic hydrolysis; and vi) reacting compound of formula (VII) with compound of formula (VIII) in the presence of solvent and base to produce compound of formula (I).
