1385184-07-5

Upstream product

• 40203-94-9 methyl (S)-2-isocyanato-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 1161-13-3 N-Cbz-L-Phe 
• 35909-92-3 N-carbobenzoxy-L-phenylalanine methyl ester 
• 1385184-04-2 C₂₄H₂₉N₃O₅ 
• 1385184-02-0 C₂₅H₂₉N₃O₆ 
• 1385184-01-9 C₈H₁₄N₂O₃*ClH 
• 1350624-45-1 C₁₃H₂₂N₂O₅ 

Downstream Products

• 1385183-79-8 C₂₈H₃₆N₄O₆ 
• 1385183-92-5 C₂₈H₃₄N₄O₆ 
• 1416992-43-2 C₂₄H₂₈N₃O₈S^(1-)*Na⁽¹⁺⁾ 

Relevant academic research and scientific papers

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors

Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the US alone. Norovirus infections constitute an important health problem for which there are no specific antiviral therapeutics or vaccines. In this study, a series of bisulfite adducts derived from representative transition state inhibitors (dipeptidyl aldehydes and α-ketoamides) was synthesized and shown to exhibit anti-norovirus activity in a cell-based replicon system. The ED 50 of the most effective inhibitor was 60 nM. This study demonstrates for the first time the utilization of bisulfite adducts of transition state inhibitors in the inhibition of norovirus 3C-like protease in vitro and in a cell-based replicon system. The approach described herein can be extended to the synthesis of the bisulfite adducts of other classes of transition state inhibitors of serine and cysteine proteases, such as α-ketoheterocycles and α-ketoesters.

Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

Series of structurally-diverse α-ketoamides and α- ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against Norwalk virus 3C protease in vitro, as well as anti-norovirus activity in a cell-based replicon system.