138523-70-3

Upstream product

• 138505-77-8 ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methyl-6-(1-oxoethyl)naphthalene-1-carboxylate 
• 138505-77-8 (1S,2S,4aR,6S,8S,8aS)-6-Acetyl-8-hydroxy-2-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid ethyl ester 
• 116097-23-5 (+)-(1S,2S,4aR,6S,8S,8aS)-1-(ethoxycarbonyl)-1,2,4a,5,6,7,8,8a-octahydro-2-methyl-6,8-naphthalenecarbolactone 
• 138505-81-4 ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dihydroxy-2-methylnaphthalene-1-carboxylate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 142437-80-7 tert-butyl 3-<(1S,2S,4aR,6S,8S,8aS)-6-<1-(ethoxycarbonyl)-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalenyl>>-3-oxopropionate 
• 142437-82-9 (1R,2R,4aS,6R,8S,8aR)-6-Acetoxy-3,4-dibromo-8-hydroxy-2-methyl-decahydro-naphthalene-1-carboxylic acid ethyl ester 
• 142437-81-8 (1R,2R,4aS,6R,8S,8aR)-6-Acetyl-3,4-dibromo-8-hydroxy-2-methyl-decahydro-naphthalene-1-carboxylic acid ethyl ester 
• 138505-80-3 ethyl (1S,2S,4aR,6R,8S,8aS)-6-acetoxy-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene-1-carboxylate 

Downstream Products

• 138505-87-0 methyl 7-<1-<(1R,2R,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-8-<(2(S)-methyl-1-oxobutyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-2-methylnaphthalenyl>>-3(R)-<(tert-butyldimethylsilyl)oxy>-5-oxohepten-6-oate 
• 138505-91-6 dihydroeptastatin 
• 138505-84-7 (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 
• 138505-86-9 (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-3-(tert-butyl-diphenyl-silanyloxy)-8-formyl-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 
• 138505-85-8 8-<(1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalenyl> 2(S)-methylbutyrate 
• 138505-83-6 (1S,2S,4aR,6R,8S,8aS)-1-<<(tert-butyldimethylsilyl)oxy>methyl>-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene 
• 138505-82-5 (1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Dihydroeptastatin, a Novel Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

The total synthesis of the novel hydroxylated HMG-CoA reductase inhibitor dihydroeptastasin (7) is described.The key C-3 hydroxyl group is introduced via Baeyer-Villiger reaction on the methyl ketone 17 which is obtained in three high-yielding steps from