138505-91-6

Usage

InChI:InChI=1/C23H38O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,13-20,22,24-26H,4,7-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13?,14-,15?,16+,17+,18+,19-,20-,22-;/m0./s1

Upstream product

• 138505-77-8 ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methyl-6-(1-oxoethyl)naphthalene-1-carboxylate 
• 138505-77-8 (1S,2S,4aR,6S,8S,8aS)-6-Acetyl-8-hydroxy-2-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid ethyl ester 
• 116097-23-5 (+)-(1S,2S,4aR,6S,8S,8aS)-1-(ethoxycarbonyl)-1,2,4a,5,6,7,8,8a-octahydro-2-methyl-6,8-naphthalenecarbolactone 
• 138505-87-0 methyl 7-<1-<(1R,2R,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-8-<(2(S)-methyl-1-oxobutyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-2-methylnaphthalenyl>>-3(R)-<(tert-butyldimethylsilyl)oxy>-5-oxohepten-6-oate 
• 138505-84-7 (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 
• 138505-88-1 methyl 7-<1-<(1S,2S,4aR,6R,8S,8aS)-6-hydroxy-8-<(2(S)-methyl-1-oxobutyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-2-methylnaphthalenyl>>-3(R)-hydroxy-5-oxoheptanoate 
• 138505-82-5 (1S,2S,4aR,6R,8S,8aS)-6-<(tert-butyldiphenylsilyl)oxy>-1,2,4a,5,6,7,8,8a-octahydro-1-(hydroxymethyl)-2-methylnaphthalene 
• 138505-89-2 (3R,5R)-3,5-Dihydroxy-7-[(1S,2S,4aR,6R,8S,8aS)-6-hydroxy-2-methyl-8-((S)-2-methyl-butyryloxy)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-heptanoic acid methyl ester 
• 142437-80-7 tert-butyl 3-<(1S,2S,4aR,6S,8S,8aS)-6-<1-(ethoxycarbonyl)-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalenyl>>-3-oxopropionate 
• 142437-81-8 (1R,2R,4aS,6R,8S,8aR)-6-Acetyl-3,4-dibromo-8-hydroxy-2-methyl-decahydro-naphthalene-1-carboxylic acid ethyl ester 
• 138505-80-3 ethyl (1S,2S,4aR,6R,8S,8aS)-6-acetoxy-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene-1-carboxylate 
• 138505-81-4 ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dihydroxy-2-methylnaphthalene-1-carboxylate 
• 138505-90-5 (1S,2S,4aR,6R,8S,8aS,4'R,6'R,2''S)-6'-<2-<1,2,4a,5,6,7,8,8a-octahydro-6-hydroxy-2-methyl-8-<(2''-methyl-1''-oxobutyl)oxy>-1-naphthalenyl>ethyl>tetrahydro-4'-hydroxy-2H-pyran-2-one 
• 138505-86-9 (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-3-(tert-butyl-diphenyl-silanyloxy)-8-formyl-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Dihydroeptastatin, a Novel Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

The total synthesis of the novel hydroxylated HMG-CoA reductase inhibitor dihydroeptastasin (7) is described.The key C-3 hydroxyl group is introduced via Baeyer-Villiger reaction on the methyl ketone 17 which is obtained in three high-yielding steps from