13855-90-8

Upstream product

• 702-50-1 2,2,5,5-tetramethylcyclohexa-1,3-dione 
• 1703-82-8 3-hydroxy-2,2,5,5-tetramethylcyclohexanone 
• 15500-76-2 Dimethyl-dimedon-mono-(toluol-4-sulfonyl-hydrazon) 

Downstream Products

• 108586-90-9 6-bromo-2,2,5,5-tetramethylcyclohex-3-enone 
• 57441-19-7 2,2,5,5-Tetramethyl-1-phenyl-cyclohex-3-enol 
• 2935-23-1 cis-Chrysanthemic acid 
• 20651-89-2 3,3,6,6-tetramethylcyclohexane-1,2-dione 
• 108586-91-0 6-hydroxy-2,2,5,5-tetramethylcyclohex-3-enone 
• 1083308-96-6 (1S)-2,2,5,5-tetramethylcyclohex-3-en-1-ol 
• 1225059-18-6 C₁₀H₁₇ClO₂ 
• 1225059-19-7 (3S,4S)-4-chloro-3-hydroxy-2,2,5,5-tetramethylcyclohexanone 
• 1092506-86-9 (1S)-(3R,4R)-3,4-dibromo-2,2,5,5-tetramethylcyclohexanol 
• 1092506-85-8 (3R,4R)-3,4-dibromo-2,2,5,5-tetramethylcyclohexanone 
• 53179-78-5 2,2-dimethyl-3R-(2',2'-dibromovinyl)-cyclopropane-1R-carboxylic acid 
• 1092506-87-0 1(S)-acetoxy-(3R,4R)-dibromo-2,2,5,5-tetramethylcyclohexane 
• 6737-14-0 4,4-dimethyl-5-(2-methyl-propenyl)-dihydro-furan-2-one 
• 827-90-7 trans-chrysanthemic acid 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS

The present invention relates to certain substituted bicyclic compounds that are agonists of RXR and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders.

Syntheses of racemic and scalemic cis-chrysanthemic acid from β,γ-unsaturated cyclohexanol

2,2,5,5-Tetramethylcyclohexane-1,3-dione is a valuable starting-material precursor of cis-chrysanthemic acid. The (1S)-stereoisomer is a precursor of pyrethrin I, the most active natural insecticide from Chrysanthemum cinerariifolium, whereas the (1R)-stereoisomer is efficiently transformed to deltamethrin, the most active commercially available pyrethroid insecticide. Several intermediates have been identified and used with variable success for that purpose.

Isomerisation of 2,2-dimethyl dimedone to (D,L) cis-chrysanthemic acid

(D,L) cis-Chrysanthemic acid has been obtained in four steps from 2,2- dimethyl dimedone which involves Bamford-Stevens olefination and tandem cyclization-Grob fragmentation reactions. (C) 2000 Published by Elsevier Science Ltd.