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Usage

Uses

Used in Pharmaceutical Synthesis:
Pyrazinecarboxylic acid, 5-cyano-, methyl ester (9CI) is used as an intermediate in the synthesis of pharmaceuticals for its potential pharmacological activity. Its unique structure allows it to be a valuable building block in the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
Pyrazinecarboxylic acid, 5-cyano-, methyl ester (9CI) is also utilized in chemical research as a model or reference substance for studying the properties and reactivity of cyanopyrazine derivatives. This can lead to a better understanding of their potential applications in various chemical and pharmaceutical processes.
Used in the Development of Novel Compounds:
Pyrazinecarboxylic acid, 5-cyano-, methyl ester (9CI) can be employed in the development of novel compounds with specific properties, such as improved stability, solubility, or bioavailability. This can be particularly useful in the design of new drugs or materials with enhanced performance characteristics.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 770-00-3 methylester of pyrazinecarboxylic acid 4-oxide 
• 2942-58-7 diethyl cyanophosphonate 
• 557-21-1 zinc(II) cyanide 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 

Relevant academic research and scientific papers

Heteroaromatic nitrile compound and application thereof

The invention discloses a heteroaromatic nitrile compound and application thereof. The invention provides a heteroaromatic nitrile compound shown as formula I or a pharmaceutically acceptable salt thereof. The compound has a good inhibition effect on CDK7.

Studies on Pyrazines. Part 22. Lewis Acid-Mediated Cyanation of Pyrazine N-Oxides with Trimethylsilyl Cyanide: New Route to 2-Substituted 3-Cyanopyrazines

Reaction of 3-substituted pyrazine 1-oxides with trimethylsilyl cyanide in the presence of triethylamine in acetonitrile gave the corresponding cyanopyrazines, yields of which depended remarkably on the substituent.Electron-donating groups enhanced the cyanation with high regioselectivity to 2-substituted 3-cyanopyrazines, while a chloro substituent suppressed the conversion.Addition of zinc halide to the reaction mixture, in most cases, increased the reactivity and improved the regioselectivity.On the other hand, the N-oxides carrying an electron-withdrawing methoxycarbonyl or N-butylcarbamoyl group underwent the cyanation, without need for the Lewis acid, to provide a mixture of nearly equal amounts of 2-substituted 3- and 5-cyanopyrazines.The latter compound was exclusively obtained when 3-methoxycarbonyl- or 3-cyanopyrazine 1-oxide was treated with diethoxyphosphoryl cyanide.