1385660-64-9Relevant academic research and scientific papers
Palladium-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion: Synthesis of 2-substituted 1H-indole-3-carboxamides
Hu, Ziwei,Liang, Dongdong,Zhao, Jiaji,Huang, Jinbo,Zhu, Qiang
, p. 7371 - 7373 (2012)
A base-controlled synthesis of 2-substituted secondary and tertiary 1H-indole-3-carboxamides through PdCl2-catalyzed cyclization of o-alkynyltrifluoroacetanilides followed by isocyanide insertion has been developed. The reaction proceeds smoothly at ambient temperature using O 2 in air as the sole oxidant of the palladium catalyst.
