1385787-05-2

Upstream product

• 929075-68-3 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-(2-oxoethyl)thymidine 
• 1385786-99-1 5'-O-amino-3'-O-(tert-butyldimethylsilyl)thymidine 
• 1385786-98-0 3'-O-(tert-butyldimethylsilyl)-5'-O-phthalimidothymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 140659-85-4 2′-deoxy-5′-O-phthalimidonucleoside 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 

Relevant academic research and scientific papers

Synthesis of thymidine dimers from 5′-O-aminothymidine

The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N-oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O-amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N-oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5-O-aminothymidine is reported. Georg Thieme Verlag Stuttgart · New York.