13858-71-4Relevant academic research and scientific papers
Preparation of Functionalized Diorganomagnesium Reagents in Toluene via Bromine or Iodine/Magnesium-Exchange Reactions
Desaintjean, Alexandre,Danton, Fanny,Knochel, Paul
supporting information, p. 4461 - 4476 (2021/08/13)
A wide range of polyfunctionalized di(hetero)aryl- and dialkenyl-magnesium reagents are prepared in toluene within 10 to 120 minutes between 78 C and 25 C via an I/Mg- or Br/Mg-exchange reaction using reagents of the general formula R2Mg (R = sBu, Mes). Highly sensitive functional groups, such as triazene or nitro, are tolerated in these exchange reactions, enabling the synthesis of various functionalized (hetero)arene and alkene derivatives after quenching with several electrophiles including allyl bromides, acyl chlorides, aldehydes, ketones, and aryl iodides.
Programmed Synthesis of Tetra-Aryl Thiophenes with Stepwise, Ester-Controlled Regioselectivity
Messina, Cynthia,Ottenwaelder, Xavier,Forgione, Pat
supporting information, p. 7348 - 7352 (2021/10/01)
Herein, we report a modular synthetic route to access tetra-arylated thiophene compounds with four different substituents with programmed chemical control provided by an ester activating/directing group. This method enables the functionalization of indivi
Base catalyzed reaction of ethyl thioglycolate with β-aryl-β-(methylthio) acroleins: A general method for the synthesis of 2-carbethoxy-5-substituted/4,5-annulated thiophenes in high overall yields
Byre Gowda,Pradeepa Kumara,Ramesh,Sadashiva,Junjappa
supporting information, p. 928 - 931 (2016/02/05)
(Methylthio) acroleins 1a-m were shown to be stable unlike their counterpart the chloroacroleins and their efficacy as 1,3-dielectrophilic properties have now been examined successfully in this work. They are shown to react with ethyl thioglycolate in the
Highly functionalized biaryls via Suzuki-Miyaura cross-coupling catalyzed by Pd@MOF under batch and continuous flow regimes
Pascanu, Vlad,Hansen, Peter R.,Bermejo G?3mez, Antonio,Ayats, Carles,Platero-Prats, Ana E.,Johansson, Magnus J.,Peric??s, Miquel ??.,Mart??n-Matute, Bel??n
, p. 123 - 130 (2015/02/19)
A diverse set of more than 40 highly functionalized biaryls was synthesized successfully through the Suzuki-Miyaura cross-coupling reaction catalyzed by Pd nanoparticles supported in a functionalized mesoporous MOF (8 wt% Pd@MIL-101(Cr)-NH2). This could be achieved under some of the mildest conditions reported to date and a strong control over the leaching of metallic species could be maintained, despite the presence of diverse functional groups and/or several heteroatoms. Some of the targeted molecules are important intermediates in the synthesis of pharmaceuticals and we clearly exemplify the versatility of this catalytic system, which affords better yields than currently existing commercial procedures. Most importantly, Pd@MIL-101-NH2 was packed in a micro-flow reactor, which represents the first report of metallic nanoparticles supported on MOFs employed in flow chemistry for catalytic applications. A small library of 11 isolated compounds was created in a continuous experiment without replacing the catalyst, demonstrating the potential of the catalyst for large-scale applications.
Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use
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Page/Page column 16, (2010/02/12)
The invention concerns novel compounds of formula (I), process for making, pharmaceutical compositions and methods of treating diseases associated with abnormal physiological behavior in the secretion and/or the activity of cysteine proteases especially c
Microwave assisted synthesis of 5-arylthiophene-2-carboxylates
Jagath Reddy,Latha,Sailaja,Pallavi,Srinivasa Rao
, p. 411 - 414 (2007/10/03)
A simple and rapid method for the synthesis of 5-Aryl-thiophene-2- carboxylates 3 has been developed by the condensation of β-chlorovinyl aldehydes 1 with mercaptoacetic acid esters 2 under microwave irradiation conditions.
