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N3PT, also known as tris(2-aminoethyl)amine, is a chemical compound belonging to the class of amines. It is a colorless liquid at room temperature with a distinctive amine odor. N3PT is recognized for its ability to form stable complexes with metal ions, making it a versatile chelating agent in various fields.
Usage:
N3PT is used as a chelating agent in Biochemistry, Medical Research, and Analytical Chemistry for its ability to form stable complexes with metal ions.
Used in Pharmaceutical Manufacturing:
N3PT is used as a component in the manufacturing of pharmaceuticals to facilitate the formation of stable complexes with metal ions, enhancing the efficacy and stability of certain drugs.
Used in Dye Production:
N3PT is used as a chelating agent in the production of dyes to improve their stability and performance.
Used in Polymer Manufacturing:
N3PT is used in the manufacturing of polymers to enhance their properties through the formation of stable complexes with metal ions.
Used in Water Treatment:
N3PT is used as a water treatment agent to remove metal ions from water, improving water quality and safety.
Used as a Corrosion Inhibitor:
N3PT is used in industrial applications as a corrosion inhibitor to protect metal surfaces from corrosion, extending the lifespan of equipment and structures.
It is important to handle N3PT with care, as it can be harmful if ingested or inhaled and can cause irritation to the skin and eyes.

13860-66-7

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13860-66-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 13860-66-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,6 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13860-66:
(7*1)+(6*3)+(5*8)+(4*6)+(3*0)+(2*6)+(1*6)=107
107 % 10 = 7
So 13860-66-7 is a valid CAS Registry Number.

13860-66-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[(2-Amino-6-methyl-3-pyridinyl)methyl]-5-(2-hydroxyethyl)-4-met hyl-1,3-thiazol-3-ium chloride hydrochloride (1:1:1)

1.2 Other means of identification

Product number -
Other names 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium,chloride hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13860-66-7 SDS

13860-66-7Relevant academic research and scientific papers

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Thomas, Allen A.,Le Huerou,De Meese,Gunawardana, Indrani,Kaplan, Tomas,Romoff, Todd T.,Gonzales, Stephen S.,Condroski, Kevin,Boyd, Steven A.,Ballard, Josh,Bernat, Bryan,DeWolf, Walter,Han, May,Lee, Patrice,Lemieux, Christine,Pedersen, Robin,Pheneger, Jed,Poch, Greg,Smith, Darin,Sullivan, Francis,Weiler, Solly,Wright, S. Kirk,Lin, Jie,Brandhuber, Barb,Vigers, Guy

, p. 2206 - 2210 (2008/12/20)

Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3′-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes α-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described.

THIOALKENEAMIDES AS TRANSKETOLASE INHIBITORS

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Page/Page column 37, (2008/06/13)

The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

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