138629-30-8

Basic information

• Product Name: (2R)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER
• Synonyms: (2R)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER;D-1-BOC-O-TBDPS-PYROGLUTAMINOL;(R)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate
• CAS NO: 138629-30-8
• Molecular Formula: C₂₆H₃₅NO₄Si
• Molecular Weight: 453.65
• Mol File: 138629-30-8.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER(138629-30-8)
• EPA Substance Registry System: (2R)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER(138629-30-8)

Safety Data

• Hazardous Substances Data: 138629-30-8(Hazardous Substances Data)

Usage

General Description

The chemical "(2R)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINECARBOXYLATE-1,1-DIMETHYLETHYL ESTER" is a complex compound with multiple functional groups. It contains a pyrrolidine ring and a carboxylate ester, and is derived from 1,1-dimethylethyl diphenylsilyloxy acetic acid. The compound also includes a methyl group and a 5-oxo functional group. With its ester and carboxylate groups, the chemical likely exhibits lipophilic properties and could potentially be used in the pharmaceutical or materials industries. The presence of the diphenylsilyl group suggests potential applications in organic synthesis or as a protectant for sensitive functional groups.

Upstream product

• 6893-26-1 D-Glutamic acid 
• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 
• 81658-25-5 2-hydroxymethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 
• 17342-08-4 (S)-Pyroglutaminol 
• 64700-65-8 methyl (2R)-pyroglutamate 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 138629-44-4 (R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-one 
• 34619-03-9 tert-butyldicarbonate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 185303-86-0 N-(tert-butoxycarbonyl)-6,7-O-isopropylidene-2,3-dideoxy-L-arabinoheptono-1,4-lactam 
• 141393-87-5 4-<(tert-butoxycarbonyl)amino>-6,7-O-isopropylidene-2,3,4-trideoxy-L-arabino-hept-2-enonic acid 1,4-lactam 

Downstream Products

• 449143-53-7 (5R)-5-(tert-butyldiphenylsilanyloxymethyl)-2-oxopyrrolidine-1,3-dicarboxylic acid 3-benzyl ester 1 tert-butyl ester 
• 885685-93-8 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-[hydroxy-(2-methoxy-phenyl)-methyl]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 173259-07-9 ethyl (2S,4S)-4-t-butoxycarbonylamino-5-t-butyldiphenylsiloxy-2-hydroxypentanoate 
• 173259-29-5 (3R,5S)-1-t-butoxycarbonyl-5-<(t-butyldiphenylsiloxy)methyl>-3-methoxymethoxy-2-pyrrolidinone 
• 173259-06-8 (3S,5S)-3-benzoyloxy-1-t-butoxycarbonyl-5-t-butyldiphenylsiloxymethyl-2-pyrrolidinone 
• 173259-08-0 ethyl (2S,4S)-4-t-butoxycarbonylamino-5-t-butyldiphenylsiloxy-2-(methoxymethoxy)pentanoate 
• 173259-25-1 ethyl (2R,4S)-4-t-butoxycarbonylamino-5-t-butyldiphenylsiloxy-2-(methoxymethoxy)pentanoate 
• 1208008-34-7 (3S)-3-((tert-butyldiphenylsilyloxy)methyl)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane 
• 1208008-33-6 (3S)-tert-butyl 3-(tert-butyldiphenylsiloxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 1180671-56-0 (1R,3S,5R)-tert-butyl 3-(5-(4-bromophenyl)-1H-imidazol-2-yl)-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 1250941-14-0 (lR,3S,5R)-3-(2-(3-bromophenyl)-2-oxoethyl) 2-tert-butyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 

Relevant articles and documents

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS

Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.