1386394-33-7

Upstream product

• 14385-63-8 (E)-3-(furan-2-yl)-1-(4-methylphenyl)prop-2-en-1-one 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 686725-78-0 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide 
• 122-00-9 para-methylacetophenone 
• 98-01-1 furfural 

Relevant academic research and scientific papers

Thiophene containing pyrazoline (or furyl) thiazole derivatives of the structure and its preparation and use

The invention relates to thiazole derivatives comprising pyrazoline and thiophene (or furan) structures, and a preparation method and an application thereof. The derivatives are characterized in that the derivatives have a general formula presented as the following, wherein R1 is as the following, R2 is H or -OCH3, and X is S or O. Specifically, when R1 is as the following, R2 is -OCH3, and X is O. The thiazole derivatives can be adopted as potential antimicrobial and antitumor medicines. The invention also discloses a preparation method thereof.

Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

A series of sulfur-containing heterocyclic pyrazoline derivatives (C1-C18; D1-D9) have been synthesized and purified (all are new except one) to screen for FabH inhibitory activity. Compound C14 showed the most potent biological activity against Escherich