14385-63-8

Basic information

• Product Name: 2-Propen-1-one, 3-(2-furanyl)-1-(4-methylphenyl)-
• CAS NO: 14385-63-8
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Mol File: 14385-63-8.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(2-furanyl)-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(2-furanyl)-1-(4-methylphenyl)-(14385-63-8)
• EPA Substance Registry System: 2-Propen-1-one, 3-(2-furanyl)-1-(4-methylphenyl)-(14385-63-8)

Safety Data

• Hazardous Substances Data: 14385-63-8(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 122-00-9 para-methylacetophenone 
• 20689-54-7 (E)-3-(2-furyl)acryloyl chloride 
• 5142-75-6 tri(p-tolyl)bismuth 
• 98-00-0 (2-furyl)methyl alcohol 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 

Downstream Products

• 114570-76-2 5-Methoxy-5-((E)-3-oxo-3-p-tolyl-propenyl)-5H-furan-2-one 
• 686725-78-0 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide 
• 60111-25-3 5-furan-2-yl-1-phenyl-3-p-tolyl-4,5-dihydro-1H-pyrazole 
• 1233824-93-5 2-(5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazole 

Relevant articles and documents

Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl) -2-phenylacetamide derivatives

A three-component, four center Ugi reaction of 3-(1-(2-aminophenyl)-5- phenyl-1H-pyrrol-2-yl)propanoic acid with aromatic aldehyde and t-butyl isocyanide has been achieved to produce a novel class of N-tert-butyl-2-(6-oxo- 11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazacine-5(6H)-yl) -2-phenylacetamides in moderate to good yields. 2013 Elsevier Ltd. All rights reserved.

Silica-supported heterogeneous catalysts-mediated synthesis of chalcones as potent urease inhibitors: in vitro and molecular docking studies

Abstract: We herein report a facile and high yielding protocol for silica-supported heterogeneous catalysts-mediated synthesis of chalcones. A comparison of results of our synthesis with conventional synthetic protocols is also being offered to assess the efficiency of the prepared catalysts. Biological evaluation of the newly synthesized compounds as urease inhibitors was performed. Most of the compounds were found to have potent urease inhibition activity. The chalcone 3-(3-hydroxyphenyl)-1-phenylpropenone was found to be the most potent with percentage inhibition 86.17 ± 0.89 and half maximal inhibitory concentration (IC50) value 11.51 ± 0.03 μM. The molecular docking study emphasized that the same congeners 3-(furan-2-yl)-1-(4-hydroxyphenyl)propenone, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)propanone, and 3-[4-(dimethylamino)phenyl]-1-(p-tolyl)propenone showed very good inhibitory potential against urease and show a higher docking scores 5718, 5940, 5596 and an ACE of ? 246.66, ? 244.79, and ? 243.06 kJ/mol, respectively than the control ligand. Graphic abstract: [Figure not available: see fulltext.].

Graphene-supported ZnO nanoparticles: An efficient heterogeneous catalyst for the Claisen-Schmidt condensation reaction without additional base

ZnO nanoparticles supported on reduced graphene oxide (ZnO/RGO) were prepared by the hydrothermal method and characterized by TEM, XPS, XRD, and Raman spectroscopy. As a green catalyst, ZnO/RGO was applied to the Claisen-Schmidt condensation reaction of aryl aldehydes and aryl ketones under microwave irradiation. Therein, chalcone products could be efficiently synthesized and easily separated from the heterogeneous catalysis system. The catalyst could be recycled four times without significant loss of catalytic activity.