138642-75-8Relevant academic research and scientific papers
New Nonpeptide Angiotensin II Receptor Antagonists> 3. Synthesis, Biological Properties, and Structure-Activity Relationships of 2-Alkyl-4-(biphenylylmethoxy)pyridine Derivatives
Bradbury, Robert H.,Allott, Christopher P.,Dennis, Michael,Girdwood, J. Alan,Kenny, Peter W.,et al.
, p. 1245 - 1254 (2007/10/02)
A novel series of nonpeptide angiotensin II (AII) receptor antagonists is reported, derived from linkage of the biphenylyltetrazole moiety found in previously described antagonists via a methyleneoxy chain to the 4-position of a 3-substituted 2,6-dialkylp
Angiotensin II antagonizers which are condensed pyridine derivatives
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, (2008/06/13)
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R1, R2, R3, R4, R5, R6, R7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
