138643-95-5Relevant academic research and scientific papers
Endothiopeptide inhibitors of HIV-1 protease
Yao, Shao,Zutshi, Reena,Chmielewski, Jean
, p. 699 - 704 (1998)
Endothiopeptide inhibitors of HIV-1 protease were synthesized by chemical and enzymatic methods to individually replace each backbone amide bond in 1 with a thioamide-linkage. Interestingly, agent 7, which contains a thioamide-linkage between the P2
Novel approaches to optically active substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones as conformationally constrained peptidomimetics
Saniere, Laurent,Schmitt, Martine,Pellegrini, Nadia,Bourguignon, Jean-Jacques
, p. 671 - 688 (2007/10/03)
Synthesis of 4,5-dihydro-1,2,4-triazin-6-ones bearing different chiral α-amino acid residues at the C3 and N1 positions is reported. Cyclocondensation of N-thioacylphthalimides with α-amino hydrazides afforded C3 functionalised dihydrotriazinones in good
