1386443-19-1

Basic information

• Product Name: 8-(4-methoxybenzoyl)-1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-one
• Synonyms: 8-(4-methoxybenzoyl)-1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-one
• CAS NO: 1386443-19-1
• Molecular Weight: 307.349
• Mol File: 1386443-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-(4-methoxybenzoyl)-1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-methoxybenzoyl)-1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-one(1386443-19-1)
• EPA Substance Registry System: 8-(4-methoxybenzoyl)-1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-one(1386443-19-1)

Safety Data

• Hazardous Substances Data: 1386443-19-1(Hazardous Substances Data)

Upstream product

• 57368-91-9 8-bromo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one 
• 100944-88-5 1-chloromethoxy-4-formylbenzene 
• 57369-32-1 pyroquilone 
• 64140-62-1 N-(β-chloropropionyl)-indoline 
• 496-15-1 1-indoline 

Downstream Products

• 1194450-83-3 8-[(1H-imidazol-1-yl)(4-methoxyphenyl)methyl]-1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one 
• 1386443-31-7 8-[hydroxy-(4-methoxyphenyl)methyl]-1,2,5,6-tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-one 

Relevant articles and documents

Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij] quinolin-4-ones as potent and selective cyp11b1 inhibitors for the treatment of cushing's syndrome

CYP11B1 inhibition is a promising therapy for Cushing's syndrome. Starting from etomidate, references I and II, the title compounds were designed and synthesized. Cyclopropyl analogue 4 was identified as a CYP11B1 inhibitor more potent (IC50 = 2.2 nM) than leads and more selective (SF = 11) than I and metyrapone. Since it also showed potent inhibition of rat CYP11B1 and good selectivity over human CYP17 and CYP19, it is a promising candidate for further development.