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• 27841-33-4 4,5-dimethoxybenzene-1,2-diamine 
• 40294-35-7 5, 6-dimethoxy-1H-1,3-benzodiazol-2-amine 
• 3395-03-7 4,5-dimethoxy-1,2-dinitrobenzene 
• 709-09-1 3,4-dimethoxynitrobenzene 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

NMR studies of N-(benzimidazol-2-yl)pyridinium derivatives: QSAR with the anti-leishmanial activity and their carbon-13 NMR chemical shifts

Quantitative structure-activity-relationships between the in vitro anti-leishmanial activity of N-benzimidazolyl-2,4,6-triphenylpyridinium salts 6 and pyridinium benzimidazolate betaines 7 and their 13C-NMR chemical shifts have been studied, in order to ascertain the influence of the benzimidazole substituents upon anti-leishmanial activity.The calculated 13C-chemical shifts allow the selection of a representative subset of compounds.Several new N-benzimidazolylpyridinium derivatives 6 and 7 have been prepared.Among them, 5-methoxy-1-methylbenzimidazole 21 and 6-methoxy-1-methylbenzimidazole 22 derivatives have high anti-leishmanial activity in vitro and compound 22 shows an interesting activity in vivo although host toxicity is present.