138683-58-6Relevant academic research and scientific papers
New antiulcer quassinoids from Eurycoma longifolia
Tada, H,Yasuda, F,Otani, K,Doteuchi, M,Ishihara, Y,Shiro, M
, p. 345 - 349 (2007/10/02)
A bioassay study of Pasak bumi (Eurycoma longifolia) led to the isolation of four quassinoids, pasakbumin-A (1), -B (2), -C (4), and -D (7).Both pasakbumin-A (= eurycomanone) 1 and pasakbumin-B 2 exhibited potent antiulcer activity.This prompted us to test some modified quassinoids to reveal that ailanthone (8), the main quassinoid of Ailanthus altissima, and its α-epoxide (9) have potent activity and less toxicity.Thus, quassinoids which are generally recognised as antitumor compounds were revealed to have antiulcer activity.
