1386985-08-5

Upstream product

• 135145-81-2 3,4,6-tri-O-triisopropylsilyl-1-iodo-D-glucal 
• 1386985-10-9 1-(3-methylphenylethynyl)glucal 
• 100-39-0 benzyl bromide 
• 1386984-93-5 1-(3-methylphenylethynyl)-3,4,6-tri-O-isopropylsilylglucal 

Downstream Products

• 1386985-22-3 1-(2-(3-methylphenyl)ethyl)-3,4,6-tri-O-benzylglucal 
• 1386985-33-6 α-1-(2-(3-methylphenyl)ethyl)-1-deoxy-3,4,6-tri-O-benzylglucose 
• 1386985-36-9 β-1-(2-(3-methylphenyl)ethyl)-1-deoxy-3,4,6-tri-O-benzylglucose 

Relevant academic research and scientific papers

Sonogashira-Hagihara reactions of halogenated glycals

Herein, we report on our findings of the Sonogashira-Hagihara reaction with 1-iodinated and 2-brominated glycals using several aromatic and aliphatic alkynes. This Pd-catalyzed cross-coupling reaction presents a facile access to alkynyl C-glycosides and sets the stage for a reductive/oxidative refunctionalization of the enyne moiety to regenerate either C-glycosidic structures or pyran derivatives with a substituent in position 2.