1386995-58-9

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 1386995-54-5 (S)-methyl 3-(benzyloxy)-2-(4-nitrophenylsulfonamido)propanoate 
• 74-89-5 methylamine 

Downstream Products

• 1386995-61-4 (S)-3-(benzyloxy)-N-methyl-2-(4-nitro-N-(3-phenylprop-2-yn-1-yl)phenylsulfonamido)propanamide 
• 1386995-62-5 (S)-3-(benzyloxy)-2-(N-(4-((tert-butyldimethylsilyl)oxy)but-2-yn-1-yl)-4-nitrophenylsulfonamido)-N-methylpropanamide 
• 1386995-63-6 (S)-3-((benzyloxy)methyl)-1-methyl-4-((4-nitrophenyl)sulfonyl)-4,5-dihydro-1H-1,4-diazepin-2(3H)-one 
• 1386995-65-8 C₂₆H₂₅N₃O₆S 
• 1386995-66-9 (S)-3-((benzyloxy)methyl)-7-(furan-2-yl)-1-methyl-4-((4-nitrophenyl)sulfonyl)-4,5-dihydro-1H-1,4-diazepin-2(3H)-one 
• 1386995-67-0 (S)-3-((benzyloxy)methyl)-1-methyl-7-phenyl-4,5-dihydro-1H-1,4-diazepin-2(3H)-one 
• 1386995-68-1 (S)-3-((benzyloxy)methyl)-1,4-dimethyl-7-phenyl-4,5-dihydro-1H-1,4-diazepin-2(3H)-one 
• 1386995-59-0 (S)-3-(benzyloxy)-N-methyl-2-(4-nitro-N-(prop-2-yn-1-yl)-phenylsulfonamido)propanamide 

Relevant academic research and scientific papers

Platinum catalyzed 7-endo cyclization of internal alkynyl amides and its application to synthesis of the caprazamycin core

The scope and limitations of the platinum catalyzed 7-endo cyclization of internal alkynyl amides were investigated. Substitution of the alkyne with an aryl group gave better results, presumably because it stabilized the transition state. Applying the reaction to a secondary amide, the caprazamycin core was successfully synthesized from commercially available material in eight steps.