1386997-96-1

Upstream product

• 1374765-83-9 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride 
• 1266784-29-5 rac-N-(2-(5-bromo-2-fluorophenyl)-1-hydroxypropan-2-yl)-2-chloroacetamide 
• 1266784-24-0 (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol 
• 1429869-71-5 rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholine-3-thione 
• 1266784-13-7 rac-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one 

Downstream Products

• 1429869-72-6 [5-(5-bromo-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester 
• 1429869-73-7 [5-(5-azido-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester 
• 1429869-74-8 [5-(5-amino-2-fluoro-phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester 
• 1429869-75-9 (5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 
• 1429869-70-4 5-{2-fluoro-5-[(furan-2-ylmethyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine 

Relevant academic research and scientific papers

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360

Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6-position of the 5-amino-1,4-oxazine, the insertion of a Me and a CF3 group delivered an excellent pharmacological profile wi

NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.