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1266784-24-0

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1266784-24-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1266784-24-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,6,7,8 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1266784-24:
(9*1)+(8*2)+(7*6)+(6*6)+(5*7)+(4*8)+(3*4)+(2*2)+(1*4)=190
190 % 10 = 0
So 1266784-24-0 is a valid CAS Registry Number.

1266784-24-0Relevant articles and documents

Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360

Rueeger, Heinrich,Lueoend, Rainer,Machauer, Rainer,Veenstra, Siem J.,Holzer, Philipp,Hurth, Konstanze,Voegtle, Markus,Frederiksen, Mathias,Rondeau, Jean-Michel,Tintelnot-Blomley, Marina,Jacobson, Laura H.,Staufenbiel, Matthias,Laue, Grit,Neumann, Ulf

supporting information, p. 4677 - 4696 (2021/05/06)

Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6-position of the 5-amino-1,4-oxazine, the insertion of a Me and a CF3 group delivered an excellent pharmacological profile wi

5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES

-

, (2015/07/07)

The present invention provides a compound of formula I' having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are

5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS

-

, (2014/01/07)

The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

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