1387007-65-9Relevant academic research and scientific papers
Highly enantioselective copper(I)-catalyzed conjugate addition of terminal alkynes to 1,1-difluoro-1-(phenylsulfonyl)-3-en-2-ones: New ester/amide surrogates in asymmetric catalysis
Sanz-Marco, Amparo,Garcia-Ortiz, Andrea,Blay, Gonzalo,Fernandez, Isabel,Pedro, Jose R.
, p. 668 - 672 (2014/01/23)
A highly enantioselective copper-catalyzed conjugate alkynylation of monoactivated enones, namely 1,1-difluoro-1-(phenylsulfonyl)-3-en-2-ones, is described. The reaction products are obtained with good yields and excellent enantioselectivities (from 92 to 99% ee). The β-alkynylated difluoro(phenylsulfonyl) ketones can be converted into the corresponding β-alkynylated difluoro- and trifluoromethyl ketones, esters and amides. This is the first example on the use of 1,1-difluoro-1-(phenylsulfonyl)-3-en-2- ones as substrates in an enantioselective reaction, which have been shown to be new ester/amide surrogates. Copyright
Enantioselective conjugate addition of alkylboranes catalyzed by a copper- N-heterocyclic carbene complex
Yoshida, Mika,Ohmiya, Hirohisa,Sawamura, Masaya
supporting information; scheme or table, p. 11896 - 11899 (2012/09/07)
The first catalytic enantioselective conjugate addition of alkylboron compounds has been achieved. Reactions between alkylboranes and imidazol-2-yl α,β-unsaturated ketones proceeded with high enantioselectivity under the influence of a Cu(I) catalyst syst
